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How an HIV Miracle Drug Vanished
In 1998, a pharmaceutical company suddenly lost the ability to make their lifesaving HIV drug at one of its production facilities. Then that failure spread to the company’s analysis labs. Then it spread to the other production facility, and within months the lifesaving drug had effectively vanished from the entire planet. And this wasn’t the first time something like this had happened. How does a chemical just… disappear?
#chemistry #medicine #crystallization #ritonavir
Producers:
Andrew Sobey
Elaine Seward
Darren Weaver
Writer:
George Zaidan
Hosts:
George Zaidan
Executive Producer:
Matthew Radcliff
Scientific Consultants:
Stephen R. Byrn, Ph. D
Leila Duman, Ph.D.
Brianne Raccor, Ph.D.
Executive in Charge for PBS: Maribel Lopez
Director of Programming for PBS: Gabrielle Ewing
Assistant Director of Programming for PBS: John Campbell
Reactions is a production of the American Chemical Society.
© 2024 American Chemical Society. All rights reserved.
Sources:
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Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development
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Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties | Pharmaceutical Research
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Ritonavir Form III: A New Polymorph After 24 Years
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Supersaturation Tower
https://www.flinnsci.com/api/l....ibrary/Download/c931
(IUCr) Why don't we find more polymorphs?
https://journals.iucr.org/b/is....sues/2013/04/00/bm50
Facts and fictions about polymorphism
https://pubs.rsc.org/en/conten....t/articlelanding/201
Disappearing Polymorphs Revisited
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NORVIR Update
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Polymorphism & Seeding: II. Case Studies
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Ritonavir: The Polymorph That Revolutionized Drug
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Disappearing Polymorphs
https://pubs.acs.org/doi/abs/10.1021/ar00052a005
The Predictably Elusive Form II of Aspirin
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Crystal Polymorphism in Chemical Process Development
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Open questions in organic crystal polymorphism
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Microgravity
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Tips for Taking RTV
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The Best Way to Temper Chocolate
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Compound Interest: The Polymorphs of Chocolate
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How many more polymorphs of ROY remain undiscovered
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Ostwald Rule of Stages─Myth or Reality?
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How to Grow Sodium Acetate Crystals
https://www.youtube.com/watch?v=2FqlAtWN2vo
Supersaturated Sodium Acetate Crystallization
https://www.youtube.com/watch?v=nrmQBdYp5tU
Crystallization.ram
https://www.youtube.com/watch?v=HoMLXFHylt8
Crystallization by Antisolvent Addition and Cooling
https://www.intechopen.com/chapters/39142
Effect of ultrasound on the kinetics of anti-solvent crystallization of sucrose
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Ritonavir Form III: A Coincidental Concurrent Discovery
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The History of HIV Treatment: Antiretroviral Therapy and More
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Recrystallization and Melting Point Analysis
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Crystallization of Sodium Acetate from a Supersaturated Solution
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Ritonavir: The Polymorph That Revolutionized Drug
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Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening
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Inconvenient Truths about Solid Form Landscapes Revealed in the Polymorphs and Hydrates of Gandotinib
https://pubs.acs.org/doi/10.1021/acs.cgd.9b00162
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