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Hydrocodone/Acetaminophen Nursing Considerations, Side Effects, and Mechanism of Action
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• 08/17/25
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Hydrocodone/Acetaminophen
Generic Name: hydrocodone/acetaminophen
Trade Name: Norco
Indication: management of moderate to severe pain
Action: alters the perception and reaction to pain by binding to opiate receptors in the CNS, also suppresses the cough reflex
Therapeutic Class: opioid Analgesic, allergy, cold and cough remedies, antitussive
Pharmacologic Class: opioid agonists, nonopioid analgesic combinations
Nursing Considerations:
use caution with concurrent use of MAOI - avoid use within 14 days of each other
hypotension - monitor hemodynamics and respirations after administering
may increase ICP use caution with head trauma
Narcan (nalaxone) is the antidote for overdose
DO NOT exceed 4g of acetaminophen per day
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