Introduction to Trimethoprim Drug ; Mechanism of action, Uses, Effects, Pharmacokinetics

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Trimethoprim is an antibiotic primarily used to treat urinary tract infections (UTIs), respiratory infections, and certain types of bacterial infections. It works by inhibiting dihydrofolate reductase, an enzyme essential for bacterial folic acid synthesis, thereby preventing bacterial growth.

Key Features
Mechanism of Action: Blocks folate metabolism, leading to bacterial cell death.

Uses: Treats bladder infections, middle ear infections, and traveler's diarrhea.

Administration: Taken orally, often combined with sulfamethoxazole for broader antibacterial coverage.

Side Effects: Can cause nausea, rash, sun sensitivity, and blood disorders.

Trimethoprim was first introduced in 1962 and remains a first-line treatment for UTIs in many countries

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