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Ketoconazole (Nizoral) – Side Effects, Uses, Mechanism of Action, Dosage, Interactions, Warnings
Ketoconazole (Nizoral) – Side Effects, Uses, Mechanism of Action, Dosage, Interactions, Warnings
Ketoconazole, sold under the brand name Nizoral, is an antifungal medication available as oral tablets, creams, shampoos, and topical solutions. It treats various fungal infections, with topical forms addressing conditions like athlete’s foot, jock itch, ringworm, dandruff, and seborrheic dermatitis, while oral tablets are reserved for severe infections like blastomycosis, histoplasmosis, and candidiasis due to potential serious side effects. Ketoconazole inhibits ergosterol synthesis, disrupting fungal cell membranes and leading to cell death. Common side effects include nausea, abdominal pain, and rashes, while serious effects may involve liver damage and hormonal changes. Dosages vary, with oral tablets typically ranging from 200–400 mg daily and topical applications used as directed. It interacts with medications such as warfarin, statins, corticosteroids, and antacids, necessitating caution due to its potent cytochrome P450 enzyme inhibition.
#Ketoconazole #Nizoral #Ketoconazoleuses #Nizoraluses #Ketoconazolesideeffects #Nizoralsideeffects
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