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Lithium Kidney Damage (Learn lithium toxicity and lithiums effect on kidney)
Learn about lithium kidney damage and lithium toxicity through learning lithiums effect on kidney.
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The video discusses the effects of lithium on the kidneys, aiming to simplify complex nephrology concepts. Lithium primarily induces nephrogenic diabetes insipidus (NDI), resulting in excessive urination and thirst due to decreased response to antidiuretic hormone (ADH). This resistance occurs because lithium disrupts ADH signaling, hindering water reabsorption in the collecting ducts. The subsequent inability to concentrate urine leads to polyuria and polydipsia. Chronic use of lithium can progress to chronic kidney disease (CKD), marked by decreased glomerular filtration rate (GFR) and potential interstitial nephritis and fibrosis. Despite this, end-stage renal disease (ESRD) from lithium is rare, occurring in a small percentage of long-term users. Management includes monitoring kidney function, maintaining lower lithium levels, and considering discontinuation in severe cases. The video emphasizes simplifying renal physiology by breaking it down into three main components: glomerulus, renal tubules, and collecting ducts. It also addresses misconceptions and clarifies terminology related to kidney function assessment and pathology. Overall, while lithium poses renal risks, careful monitoring and management can mitigate adverse effects.
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#lithium #bipolar #bipolardisorder
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00:00 Ready, Able to Learn Nephrology
00:10 Introduction, Lithium's Effect on the Kidney
01:12 Nephron's For Dummies
02:26 Etymology of Diabetes
03:13 Collecting Duct
03:40 Anti-diuretic Hormone (ADH) Review
04:33 How Lithium Causes Nephrogenic Diabetes Insipidus
07:29 Chronic Kidney Disease
08:15 Lithium's Overall Impact on Kidney
12:51 Outro
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