Low-Dose Naltrexone: Hype, Hope, or Homerun?

Low-Dose Naltrexone: Hype, Hope, or Homerun? | Sean Mackey, M.D., Ph.D.

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This clip is from episode #345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.
In this clip, they discuss:

- What Is Low-Dose Naltrexone? – An overview of how LDN differs from traditional naltrexone used in addiction treatment
- Mechanism of Action at Low Doses – How transient opioid receptor blockade might trigger downstream anti-inflammatory effects
- LDN and Inflammation – Why some clinicians and patients are exploring LDN as a tool for managing inflammation-related conditions
- LDN’s Surprising Effects – Reports suggest LDN may improve mood or energy, but the science is still emerging
- Why the Data Is Still Preliminary – While promising anecdotally, LDN still lacks large-scale clinical trials for most of its off-label uses

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The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.

Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.

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