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Neomycin Tablet क्यों use नहीं होती? | side effects of Neomycin | Uses of antibiotic Neomycin
Neomycin Tablet क्यों use नहीं होती? | side effects of Neomycin | Uses of antibiotic Neomycin
In this video you'll know about Neomycin Tablet
It is active against most gram negative bacilli
and some gram positive cocci.
Neomycin is highly toxic to the internal ear (mainly auditory) and kidney, hence it is not preferred to be used systemically.
It is poorly absorbed from the G.I.T.
It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Indications:
Orally used for bacterial diarrhoeas and dysentery.
Preparation of bowel before surgery
Hepatic coma
Dosage:
0.25-1 gm four times
Contra indications:
Hypersensitivity to aminoglycosides
renal impairment
Prolonged use can induce malabsorption syndrome with diarrhoea and steatorrhoea.
It decreases absorption of digoxin, bile acid reabsorption and lowers plasma cholesterol levels.
Paediatrics: Use with caution
Pregnancy: Contraindicated
Lactation: Contraindicated
Elderly: Use with caution.
Side- effects:
Ototoxicity
Nephrotoxicity
Nausea
Vomiting
Diarrhoea
Drug interactions : Potentiates nephrotoxicity produced
by other aminoglycosides, neuromuscular blocking action of
tubocurarine and pancuronium. Potentiates ototoxic effect
of loop diuretics. Interferes with absorption of digoxin, phe-
noxymet-hylpenicilline, Vit. B12, Methotrexate, 5-flurouracil
and spironolactone. Cholestercl lowering
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