Bumetanide is a loop diuretic that works by inhibiting sodium, potassium, and chloride reabsorption in the ascending loop of Henle. This leads to increased urine output, reducing fluid retention and blood pressure2.

Pharmacokinetics
Absorption: Rapidly absorbed orally

Metabolism: Partially hepatic

Excretion: Urine (~81%) and feces (~2%)

Onset of Action: Oral: 30–60 minutes; IV: 2–3 minutes

Peak Effect: Oral: 1–2 hours; IV: 15–30 minutes

Duration of Action: Oral: 4–6 hours; IV: 2–3 hours

Half-Life: 1–1.5 hours (longer in neonates)

Protein Binding: 94–96%

Mechanism of Action
Bumetanide blocks the sodium-potassium-chloride (NKCC2) symporter in the thick ascending limb of the loop of Henle, preventing sodium reabsorption. This results in natriuresis (sodium loss) and diuresis (fluid loss), making it effective for edema and hypertension3.

Uses
Bumetanide is used to treat:

Edema associated with heart failure, liver disease, and kidney disease

Acute pulmonary edema

Hypertension (off-label use)

#Bumetanide

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Pharmacology of Bumetanide (Bumex) ; Mechanism of action, Uses, Effects, Pharmacokinetics

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