- Ozempic
- Mounjaro
- Wegovy
- Semaglutide
- Retinol
- Finasteride
- Metformin
- Wellbutrin
- Melatonin
- Ashwagandha
- Lexapro
- Sertraline
- Creatine
- Prozac
- Fluoxetine
- Pregabalin
- Spironolactone
- Amlodipine
- Trazodone
- Akathisia
- Steroids
- Prednisone
- Doxycycline
- Tramadol
- Lisinopril
- Losartan
- Amoxicillin
- Androgenic
- Azithromycin
- Zoloft
- Statin
- Atorvastatin
- Acetylcysteine
- Adderall
- Alprazolam
- Amitriptyline
- Augmentin
- Cetirizine
- Cipro
- Clonazepam
- Clotrimazole
- Diazepam
- Fentanyl
- Gabapentin
- Hydroxyzine
- Ibuprofen
- Ivermectin
- Lorazepam
- Magnesium
- Meloxicam
- Metoprolol
- Metronidazole
- Mirtazapine
- Naproxen
- Omega 3
- Omeprazole
- Ondansetron
- Paracetamol
- Propranolol
- Quetiapine
- Sildenafil
- Tamsulosin
- Tirzepatide
- Tylenol
- Viagra
- Vitamin B12
- Vitamin C
- Vitamin D
- Xanax
- Acetaminophen
- Acyclovir
- Advil
- Albendazole
- Albuterol
- Alendronate
- Alfuzosin
- Allopurinol
- Amantadine
- Ambien
- Ambroxol
- Amiodarone
- Ampicillin
- Anastrozole
- Apixaban
- Aripiprazole
- Ascorbic Acid
- Aspirin
- Atarax
- Atenolol
- Ativan
- Atomoxetine
- Azelastine
- Bacitracin
- Baclofen
- Bactrim
- Bactroban
- Benadryl
- Bentyl
- Benzonatate
- Benztropine
- Betadine
- Betamethasone
- Biktarvy
- Biotin
- Bisacodyl
- Bisoprolol
- Botox
- Brilinta
- Budesonide
- Glycopyrrolate
- Bumetanide
- Buprenorphine
- Bupropion
- Buspar
- Buspirone
- Calcitriol
- Candesartan
- Captopril
- Carbamazepine
- Carvedilol
- Cefdinir
- Cefixime
- Ceftriaxone
- Cefuroxime
- Celebrex
- Celexa
- Cephalexin
- Chlorpheniramine
- Chlorthalidone
- Cholecalciferol
- Cialis
- Cilostazol
- Citalopram
- Claritin
- Clindamycin
- Clobetasol
- Clonidine
- Clopidogrel
- Clozapine
- Codeine
- Colace
- Colchicine
- Concerta
- Cosentyx
- Crestor
- Cyanocobalamin
- Cyclobenzaprine
- Cymbalta
- Dabigatran
- Dapagliflozin
- Decadron
- Denosumab
- Depakote
- Desloratadine
- Desvenlafaxine
- Dexamethasone
- Dexilant
- Dextroamphetamine
- Dextromethorphan
- Dextrose
- Dicyclomine
- Diflucan
- Digoxin
- Dilaudid
- Diltiazem
- Diphenhydramine
- Divalproex
- Docusate Sodium
- Domperidone
- Donepezil
- Dopamine
- Doxazosin
- Doxepin
- Doxycycline Hyclate
- Doxylamine
- Dulcolax
- Duloxetine
- Dupixent
- Dutasteride
- Echinacea
- Effexor
- Eliquis
- Empagliflozin
- Enalapril
- Epinephrine
- Epipen
- Erythromycin
- Escitalopram
- Esomeprazole
- Estradiol
- Euthyrox
- Excedrin
- Ezetimibe
- Famotidine
- Farxiga
- Febuxostat
- Fenofibrate
- Ferrous Sulfate
- Fexofenadine
- Fish Oil
- Flagyl
- Flecainide
- Flexeril
- Flomax
- Flonase
- Fluticasone
- Fluvoxamine
- Folic Acid
- Formoterol
- Fosamax
- Fosfomycin
- Furosemide
- Gardasil 9
- Garlic
- Gas X
- Gaviscon
- Gentamicin
- Ginkgo Biloba
- Ginseng
- Glimepiride
- Glipizide
- Glucagon
- Glucophage
- Glucosamine
- Glutathione
- Glycerin
- Griseofulvin
- Guaifenesin
- Guanfacine
- Haldol
- Haloperidol
- Heparin
- Hibiclens
- Humira
- Hydralazine
- Hydrea
- Hydrochlorothiazide
- Hydrocodone
- Hydrocortisone
- Hydromorphone
- Hydroxyurea
- Hyoscyamine
- Imiquimod
- Imodium
- Indapamide
- Inderal
- Indomethacin
- Infliximab
- Irbesartan
- Isosorbide
- Isosorbide Mononitrate
- Isotretinoin
- Itraconazole
- Ivabradine
- Janumet
- Januvia
- Japanese Knotweed
- Jardiance
- Kava
- Keflex
- Kenalog
- Keppra
- Ketoconazole
- Ketoconazole Shampoo
- Ketoprofen
- Ketorolac
- Keytruda
- Klonopin
- Labetalol
- Lacosamide
- Lactulose
- Lamictal
- Lamotrigine
- Lansoprazole
- Lantus
- Lasix
- Latanoprost
- Latuda
- Leflunomide
- Letrozole
- Levetiracetam
- Levocetirizine
- Levofloxacin
- Levothyroxine
- Lidocaine
- Linezolid
- Linzess
- Lipitor
- Liraglutide
- Lisdexamfetamine
- Lithium
- Lokelma
- Lomotil
- Loperamide
- Loratadine
- Lovenox
- Lyrica
- Macrobid
- Magnesium Citrate
- Magnesium Oxide
- Meclizine
- Medrol
- Mefenamic Acid
- Memantine
- Meropenem
- Metamucil
- Methadone
- Methimazole
- Methocarbamol
- Methotrexate
- Methylphenidate
- Methylprednisolone
- Metoclopramide
- Metoprolol Succinate
- Midazolam
- Midodrine
- Mirabegron
- Miralax
- Mobic
- Modafinil
- Montelukast
- Morphine
- Motrin
- Moxifloxacin
- Mucinex
- Mupirocin
- Nac
- Naloxone
- Naltrexone
- Narcan
- Nebivolol
- Neomycin
- Neosporin
- Neurontin
- Nexium
- Nexplanon
- Niacin
- Nifedipine
- Nitrofurantoin
- Nitroglycerin
- Norco
- Norepinephrine
- Norethindrone
- Nortriptyline
- Norvasc
- Octreotide
- Ofloxacin
- Olanzapine
- Olmesartan
- Orlistat
- Oseltamivir
- Oxazepam
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Oxycontin
- Oxygen
- Paroxetine
- Paxil
- Paxlovid
- Pepcid
- Percocet
- Phenazopyridine
- Phenergan
- Phenobarbital
- Phentermine
- Phenylephrine
- Phenytoin
- Pioglitazone
- Plan B
- Plaquenil
- Plavix
- Potassium Chloride
- Pradaxa
- Pravastatin
- Prazosin
- Prednisolone
- Prilosec
- Pristiq
- Prochlorperazine
- Progesterone
- Prolia
- Promethazine
- Propofol
- Protonix
- Pseudoephedrine
- Psyllium
- Pyridium
- Quercetin
- Quinine
- Rabeprazole
- Ramipril
- Ranitidine
- Ranolazine
- Reglan
- Remeron
- Repatha
- Rexulti
- Rifaximin
- Rinvoq
- Risperdal
- Risperidone
- Ritalin
- Rituximab
- Rivaroxaban
- Rizatriptan
- Robaxin
- Rocephin
- Rosuvastatin
- Rybelsus
- Salbutamol
- Scopolamine
- Senna
- Senokot
- Seroquel
- Simvastatin
- Singulair
- Sitagliptin
- Skyrizi
- Sodium Bicarbonate
- Sodium Chloride
- Solifenacin
- Soma
- Sotalol
- Spiriva
- Strattera
- Suboxone
- Sucralfate
- Sudafed
- Sulfasalazine
- Sumatriptan
- Symbicort
- Synthroid
- Tacrolimus
- Tadalafil
- Tamiflu
- Tamoxifen
- Tegretol
- Telmisartan
- Temazepam
- Tetracycline
- Thiamine
- Ticagrelor
- Tizanidine
- Topamax
- Topiramate
- Toradol
- Torsemide
- Tranexamic Acid
- Tremfya
- Tresiba
- Tretinoin
- Triamcinolone
- Triamcinolone Acetonide
- Trileptal
- Trimethoprim
- Trintellix
- Trulicity
- Ubrelvy
- Ultracet
- Unisom
- Urea
- Urea Cream
- Urso
- Ursodiol
- Valacyclovir
- Valium
- Valsartan
- Valtrex
- Vancomycin
- Varenicline
- Venlafaxine
- Ventolin
- Veozah
- Verapamil
- Vicodin
- Victoza
- Vistaril
- Vitamin B6
- Vitamin D3
- Vitamin E
- Vraylar
- Vyvanse
- Warfarin
- Witch Hazel
- Wormwood
- Xarelto
- Xenical
- Xifaxan
- Xolair
- Xylitol
- Xyzal
- Yarrow
- Yasmin
- Yaz
- Yellow Fever Vaccine
- Zantac
- Zepbound
- Zetia
- Zinc
- Zithromax
- Zofran
- Zoladex
- Zolpidem
- Zopiclone
- Zovirax
- Zyprexa
- Zyrtec
- Hydroxytryptophan
- Serious
- Other
PHARMACOLOGY OF Degarelix (Firmagon); Overview, mechanism of action, Uses, Effects, Pharmacokinetics
Degarelix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used primarily in the treatment of advanced prostate cancer. Here's an overview of its pharmacology:
Mechanism of Action:
GnRH Receptor Antagonist: Degarelix binds to GnRH receptors in the anterior pituitary gland, blocking the interaction with GnRH. This results in a rapid and sustained reduction in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Testosterone Suppression: The reduction in LH and FSH levels leads to a decrease in testosterone production, which is crucial for the management of prostate cancer.
Pharmacokinetics:
Absorption: Degarelix is administered subcutaneously and is rapidly absorbed.
Distribution: It has a volume of distribution greater than 1000 L.
Metabolism: Degarelix is metabolized via peptide hydrolysis in the liver.
Excretion: The drug and its metabolites are excreted primarily via the feces (70-80%) and to a lesser extent via the urine (20-30%).
Elimination Half-Life: The elimination half-life is approximately 53 days for the loading dose and 31 days for the maintenance dose.
Clinical Use:
Advanced Prostate Cancer: Degarelix is indicated for the treatment of advanced hormone-dependent prostate cancer in adult males. It is used to achieve and maintain suppression of testosterone levels3.
Side Effects:
Common Side Effects: Injection-site reactions (pain, erythema, swelling), hot flushes, and weight gain.
Serious Side Effects: Potential for allergic reactions, liver enzyme abnormalities, and cardiovascular events.
#Degarelix
SORT BY-
Top Comments
-
Latest comments