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Pharmacology of Imiquimod (Aldara) ; Pharmacokinetics, Mechanism of Action, Uses, Effects
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• 08/19/25
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Imiquimod, marketed as Aldara, is a topical immune response modifier used to treat various dermatological conditions. It is primarily indicated for:
Actinic keratosis (AK) on the face or scalp.
Superficial basal cell carcinoma (sBCC) when surgical methods are less appropriate.
External genital and perianal warts caused by the human papillomavirus (HPV).
Mechanism of Action: Imiquimod stimulates the innate and adaptive immune responses by inducing the production of cytokines, such as interferon-alpha, tumor necrosis factor-alpha, and interleukins. This immune activation helps combat viral infections and abnormal cell growth.
Pharmacokinetics: When applied topically, systemic absorption is minimal. The drug is metabolized in the liver and excreted primarily through urine and feces.
Side Effects: Common side effects include local skin reactions (redness, swelling, and erosion) and flu-like symptoms (fever, fatigue). Severe inflammatory reactions may require dose adjustments or discontinuation
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