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Pharmacology of meclizine (Antivert) ; Mechanism of action, Pharmacokinetics, Uses, Effects
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• 08/24/25
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Meclizine is an antihistamine used primarily to treat motion sickness and vertigo. Here's a brief overview of its pharmacology:
Mechanism of Action
Meclizine works by blocking histamine H1 receptors. This action helps reduce symptoms like nausea, vomiting, and dizziness associated with motion sickness and vertigo1.
Pharmacokinetics
Onset of Action: About 30-60 minutes.
Duration of Action: Approximately 12-24 hours.
Half-Life: Around 5.2 hours.
Metabolism: Primarily metabolized in the liver to norchlorcyclizine.
Excretion: Excreted through urine and feces as unchanged drug and metabolites.
Indications
Motion Sickness: Prevents and treats nausea, vomiting, and dizziness.
Vertigo: Controls vertigo associated with vestibular system diseases.
Dosage
Adults and children 12 years and older: 25-50 mg once daily for motion sickness, 25-100 mg daily for vertigo.
Timing: For motion sickness, take 25-50 mg one hour before travel.
Side Effects
Common: Drowsiness, dry mouth.
Less Common: Blurred vision.
Precautions
Use with caution in patients with asthma, glaucoma, or prostate enlargement due to its anticholinergic effects.
Avoid use in pregnancy unless clearly needed
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