Pharmacology Of phenazopyridine ; Mechanism of Action, Pharmacokinetics, Uses, Effects

0 Views • 08/25/25

Side Effects

Subscribers

Phenazopyridine is a non-opioid analgesic used primarily for the symptomatic relief of pain, burning, urgency, frequency, and discomfort in the lower urinary tract. Here are some key points about its pharmacology:

Mechanism of Action
Phenazopyridine works as a local anesthetic. It exerts its analgesic effect by numbing the mucous membranes of the urinary tract, providing relief from irritation and discomfort.

Pharmacokinetics
Absorption: Phenazopyridine is well absorbed orally.

Distribution: It is distributed throughout the body, with a small amount entering the cerebrospinal fluid.

Metabolism: It is extensively metabolized in the liver.

Excretion: The drug is excreted primarily in the urine, which often turns an orange to reddish color.

Onset of Action: The onset of action is typically within 30-60 minutes after oral administration.

Duration of Action: The effects last for about 6-8 hours.

Half-Life: The elimination half-life is approximately 7-9 hours.

Side Effects
Common side effects include:

Nausea and gastric disturbances

Headache

Orange to red-colored urine

Dizziness

Rash and pruritis (itching)

Jaundice in rare cases

Contraindications
Phenazopyridine should not be used in patients with:

Hypersensitivity to phenazopyridine

Severe liver disease or renal impairment

Glomerulonephritis or pyelonephritis during pregnancy

Precautions
Avoid contact lenses while using phenazopyridine, as it can permanently discolor them.

Avoid driving or operating machinery that requires alertness, as it may cause dizziness.

Uses
Phenazopyridine is used for symptomatic relief of discomfort caused by:

Urinary tract infections (UTIs)

Surgery or trauma to the urinary tract

Endoscopic procedures

Insertion of catheters or other instruments

#phenazopyridine

Up next

Pharmacology Of phenazopyridine ; Mechanism of Action, Pharmacokinetics, Uses, Effects

Up next

Please note that if you are under 18, you won't be able to access this site.

Up next

Pharmacology Of phenazopyridine ; Mechanism of Action, Pharmacokinetics, Uses, Effects

Up next

Language