What is prochlorperazine used for?

Prochlorperazine suppositories and tablets are used to control severe nausea and vomiting. Prochlorperazine tablets are also used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions).

Prochlorperazine tablets are also used on a short-term basis to treat anxiety that could not be controlled by other medications. Prochlorperazine should not be used to treat any condition in children who are younger than 2 years old or who weigh less than 20 pounds (about 9 kilograms). Prochlorperazine is in a class of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.

How to use Prochlorperazine?

Prochlorperazine comes as a tablet to take by mouth and as a suppository to place in the rectum. Prochlorperazine tablets are usually taken three to four times a day by adults and are usually given to children one to three times a day. Prochlorperazine suppositories are usually inserted twice a day.
Use prochlorperazine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Use prochlorperazine exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Your doctor may start you on a low dose of prochlorperazine and gradually increase your dose, not more often than once every 2-3 days.

If you are using prochlorperazine to treat schizophrenia, prochlorperazine may help control your symptoms but will not cure your condition. Continue to use prochlorperazine even if you feel well. Do not stop using prochlorperazine without talking to your doctor. If you suddenly stop using prochlorperazine, you may experience withdrawal symptoms such as nausea, vomiting, dizziness, and shakiness.

To insert a prochlorperazine suppository, follow these steps:
Wash your hands thoroughly with soap and water.
If the suppository is soft, hold it under cool water or place it in the refrigerator for a few minutes to harden it before removing the wrapper.
Remove the wrapper, if present.
If you were told to use half of the suppository, cut it lengthwise with a clean, sharp blade.
Put on a finger cot or disposable glove, if desired (available at a pharmacy).
Lubricate the suppository tip with a water-soluble lubricant such as K-Y Jelly, not petroleum jelly (Vaseline). If you do not have this lubricant, moisten your rectal area with cool tap water.
Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach.
Lift upper buttock to expose the rectal area.
Insert the suppository, pointed end first, with your finger until it passes the muscular sphincter of the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and 1 inch (2.5 centimeters) in adults. If not inserted past this sphincter, the suppository may pop out.
Hold buttocks together for a few seconds.
Remain lying down for about 15 minutes to avoid having the suppository come out.
Try to avoid having a bowel movement for about an hour so that the medication in the suppository can be absorbed into the body.
Discard used materials and wash your hands thoroughly.

What side effects can this medication cause?

Prochlorperazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

dizziness, feeling unsteady, or having trouble keeping your balance.
blurred vision.
dry mouth.
stuffed nose.
headache.
nausea.
constipation.
difficulty urinating.
widening or narrowing of the pupils (black circles in the center of the eyes).
increased appetite.
weight gain.
agitation.
jitteriness.
difficulty falling asleep or staying asleep.
blank facial expression.
drooling.
uncontrollable shaking of a part of the body.
shuffling walk.
breast enlargement.
breast milk production.
missed menstrual periods.
decreased sexual ability in men.

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