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Skyrizi is used to treat psoriasis.

It’s mechanism of action is that it's an interleukin blocker. What that means is that eventually it's going to decrease the number of cytokines and chemokines that are produced in your body.

These substances are basically signaling proteins that lead to inflammation in your body.

Dosage

Skyrizi has a unique dosing schedule.

First of all Skyrizi comes in a 75 mg strength that you inject subcutaneously. You give two injections or 150 mg on day one, then you give 150 mg 4 weeks later, then you start giving 150 mg every 12 weeks.

The first month of dosing is what's referred to as a “loading dose”. The idea is to get your blood levels up a little higher earlier on and then level you out with the every 12 week dosing

Side Effects

Skyrizi does have some side effects that you need to be aware of.

First of all you can develop antibodies to use in Skyizi. This means that your body begins to develop antibodies to the drug and it can become less effective the longer you use it. You can see this in up to 24% of people who use it.

About 14% of people who use it can develop neutralizing antibodies. These types of antibodies actually make the drug ineffective.

The other type of side effect you can see is higher infection rates.

Remember Skyrizi acts on chemokines and cytokines. While they are involved in the inflammatory process remember that inflammation isn't always a bad thing. Part of your immune response involves inflammation. So when you knock that down it can lead to more infections.

You can see higher infection rate in up to 22% of users. Some of the more common infections tend to be upper respiratory tract infections and fungal infections.

I also warn people that you can see headaches in a small group of users as well as fatigue. But again these are only 3% to 4% of users.

One of the other things I get asked is if Skyrizi can cause weight loss?

It's actually not listed as one of the potential side effects for the drug. But keep in mind if you find that you're losing weight pay attention to if you are getting any sort of infections. If you're not feeling well because of infection there can be weight loss. But as far as Skyrizi directly affecting weight loss I think it's a long shot.

Because the drug can affect your immune system your doctor is likely going to monitor your labs throughout your use. I'll also test you for tuberculosis and monitor that as well.

How Long Does It Take To Work?

Skyrizi takes 3 to 14 days to reach peak blood levels. That doesn't mean it will take that long to start working. You may notice changes sooner.

But as far as peak effectiveness you're probably going to be looking at giving yourself at least a week or two on the medication to notice a change.

One of the biggest issues you see with people who want to use Skyrizi is that it costs quite a bit of money.

Sometimes we don't have any issues getting it through insurance other times you will. If that's the case you may want to look into financial assistance.

Here's a link to Skyrizi’s financial assistance program check it out see if you qualify: https://www.abbvie.com/patient....s/patient-assistance

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