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STATINS [USES,SIDE EFFECTS AND MONITORING]
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• 08/28/25
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They are called HMG CoA Reductase Inhibitors (Hydroxylmethyl glutaryl Co A)
E.g. Atorvastatin
Rosuvastatin
Fluvastatin
Pita vastatin
Simvastatin
Lovastatin
Pravastatin
Statins generally:
Strong LDL lowering effect
Rosuvastatin is more potent than Atorvastatin
Rosuvastatin and Atorvastatin are more potent than the rest
Fluvastatin is least potent
Fluvastatin, Pitavastatin and Pravastatin are less likely to have drug interactions or muscle toxicity compared to the rest statins
High dose of simvastatin can lead to more myopathy and Rhabdomyolysis
Statins and bile acid sequestrant = synergistic effects
Statins + Ezetimibe = fine
CK is very useful to detect serious complications as:
Myalgia = No rise in CK
Myopathy =CK greater than 5 times
Mild Myositis
Painful muscles/ weakness/ cramps
CK greater than 10 times
Rhabdomyolysis = CK greater than 20,000 u/l
Myoglobinuria
Severe muscle pain
More in females
More in elderly
More in hypothyroidism
More in patients on cyclosporin, erythromycin and Gemfibrozil
You will also educate yourself more,if you listen to this presentation.
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