Sumatriptan also known as Triptans. It is a selective agonist of serotonin receptor also known as 5 hydroxy tryptamine 1B and 1D receptor located in cranial blood vessels.
It is sold under the brand names, Sumitrex, Sumitop so on. During migraine, Trigeminal nerve becomes activated this results in the release of neuropeptides from Cranial nerve 5. Neuropeptides cause painful neurogenic inflammation in the meningeal vascular causing vasodilation and activation of nociceptors, all of which contributes to the migraine. Clinically, Sumatriptan is used for treating acute migraine attack. Overdosing of Sumatriptan results in Sulfhaemoglobinaemia that makes our blood appear dark green.
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Sumatriptan serotonin agonist | MOA |Sulfhaemoglobinemia | adverse effects

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