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Thiazides Diuretics: Types, Mechanism of Action, Therapeutic Uses and Adverse Effects

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In this video, I talk about Thiazides which are commonly used to treat hypertension. They include the true thiazides like hydrochlorothiazide and bendroflumethiazide. They also include the thiazide like agents like Chlorthalidone, indapamide and metolazone...

Thiazides work by inhibiting the Nacl cotransporter in the proximal part of the distal convoluted tubule and that lead to losing 7% sodium and 7% water and also K, Cl, H, Mg...

They also have a lot of side effects linked to them like hypovolemia, hyponatremia, hypomagnesemia, hypokalemic metabolic alkalosis, hyperglycemia and hyperlipidemia...
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**Diuretic Series link: https://www.youtube.com/playli....st?list=PLllTTKSgGCn
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*** The pictures used in the thumbnail of this video are licensed under creative commons licensing, credit for both of these pictures: Tomino de WS, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons
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Why thiazides used for hypertension ?

Video Timestamps
0:00 Introduction
0:52 Types
2:26 Pharmacokinetics
4:46 Mechanism of Action
10:44 Therapeutic Uses
17:33 Adverse Effects

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