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Trintellix: The Game Changer
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• 08/28/25
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Trintellix (vortioxetine, formerly Brintellix), a multimodal serotonergic antidepressant, is a truly novel agent that increases not only all three monoamines (serotonin, dopamine and norepinephrine), but also glutamate, acetylcholine, and histamine. It causes less nausea and sexual dysfunction than its cohorts, and its pro-histaminergic properties and antagonism at the serotonin 7 receptor are thought to mediate unique cognitive benefits for some patients. In my own professional experience, I witnessed first-hand the robust improvements experienced by patients suffering from true endogenous illness upon switching to vortioxetine.
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