Ubrelvy For Migraine Relief: Is It A Good Choice For You?

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What Is Ubrelvy Used For?

Ubrelvy is a new oral medication used to treat migraine attacks. There are other drugs in the same drug class as Ubrelvy but they are all injectables and are designed to prevent migraines - not treat attacks.

This new class of drug is called CGRP blockers. We know that when you get a migraine one of the things that can happen is you can get inflammation and pain and we know a substance called CGRP plays a role in that. These drugs block CGRP which can lower or prevent that inflammation and pain.

This is different than the other major class of drugs that are used to treat acute migraines, the “triptans” (for example, sumatriptan which also goes by the brand name Imitrex). They act by constricting blood vessels in the brain.

Dosage

Ubrelvy comes in 50 and 100 mg doses. It's designed to be taken 50 to 100 mg at the onset of a migraine.

If you still have symptoms from your migraine in 2 hours you can take another dose. The normal Max dose per day is 200 mg.

However, if you have any liver or kidney disease your doctor is going to need to make sure to drop your dose down. This means you won't be able to take more than 100mg a day it's a Max dose. Again your doctor is going to have to draw your blood labs to see if that's a concern for you.

Side Effects

Overall Ubrelvy is a drug that's very well tolerated and doesn't have a lot of side effects.

Most common side effects are nausea and drowsiness with nausea occurring in about three to four percent of people. And drowsiness happening in about two to three percent of people in studies.

How Long Does It Take To Work?

Of course one of the biggest questions when you take you probably is how long will it take to start getting rid of migraine.

That's going to differ for each person but it takes one and a half hours for your blood levels to reach their maximum. So for sure you'll see something in that time frame. But it could be as little as 15 minutes to more like half hour to an hour before you really notice a difference

Contraindications?

Like I mentioned above Ubrelvy is pretty safe but there are certain people where it's not a good choice.

If you have any sort of serious kidney disease you're going to have a tough time clearing the drug from your system. So it may not be the best choice.

Again, your doctor will measure your labs to see if you fall in that category.

Drug Interactions

While Ubrelvy is not known for having drug interactions you do need to be very careful with what are called CYP3A4 inhibitors.

Basically CYP3A4 is a liver enzyme. And it helps break drugs down and gets them eliminated from your system. But certain drugs can actually block this enzyme.

When they're strong blockers of the things that can happen is you'll get a buildup of Ubrelvy in your system. So these combinations should be avoided. The main groups of drugs that are strong Inhibitors of this enzyme are: macrolide antibiotics (i.e., erythromycin), 'azole' antifungals (i.e., fluconazole) and HIV meds.

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