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Update: FDA Approves Apalutamide (Erleada) for Metastatic Castration-Sensitive Prostate Cancer
PCRI’s Executive Director, Mark Scholz, MD, announces that Erleada (apalutamide) has been FDA-approved for use in a new group of prostate cancer patients. Up until now, Erleada was only FDA-approved for the treatment of castrate-resistant prostate cancer (that is, prostate cancer that is resistant to Lupron or another first-generation hormone treatment) but now, Erleada has been approved for concurrent use with Lupron (or a Lupron type drug) in men with metastatic castrate-sensitive disease.
0:12 Erleada is a second-generation hormonal treatment that is effective at treating advanced prostate cancer. Up until now, it has only been used to treat prostate cancer that was resistant to first-generation treatments (Casodex, Lupron, etc.) known as "castrate-resistant prostate cancer."
0:27 A large 1000-person prospective trial was conducted to test Erleada's effectiveness when added to Lupron in men with metastatic castrate-sensitive prostate cancer. Researchers found improved survival and better outcomes in men when Erleada was added to Lupron. Hence, the FDA approved Erleada for the treatment of this stage of prostate cancer.
0:45 Men with metastatic castrate-sensitive prostate cancer are usually in a situation in which, for whatever reason, their PSAs were not being monitored and it rose to a very high level without treatment. Historically, they would be treated with Lupron alone, Lupron plus chemotherapy (e.g. Taxotere), or Lupron plus Zytiga (another second-generation hormonal agent).
1:39 Erleada is typically well-tolerated. Some men experience a rash, but in most cases, there are no additional side effects than when Lupron is taken alone.
Don’t know your stage? Take the quiz: Visit http://www.prostatecancerstaging.org
To learn more about prostate cancer visit http://www.pcri.org
To download the free Staging Guide visit http://www.pcri.org/prostate-cancer-s...
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
#ProstateCancer #Prostate #MarkScholzMd
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