In this high-yield medical education video, we explore hydroxocobalamin — a lesser-known but powerful adjunct vasopressor used in vasoplegic shock and cyanide toxicity. Learn how this vitamin B12 analog exerts potent effects on vascular tone and when to use it in the ICU.

📌 What you’ll learn in this video:
What is hydroxocobalamin?
Mechanism of action: nitric oxide scavenger, catecholamine-sparing effects
Clinical uses in vasoplegic shock, cyanide poisoning, and refractory hypotension
Receptor-independent vasoconstriction explained simply
Dosing strategies and administration pearls
Side effects: red discoloration, lab interference, hypertension
Key clinical evidence and use in cardiac surgery or critical care
Summary + board-style practice questions
🎯 Ideal for learners preparing for USMLE Step 2/3, critical care boards, or managing shock and toxicologic emergencies in the ICU or ED.

📚 Related Resources:
Download our hydroxocobalamin study guide and practice questions: https://www.patreon.com/collection/1443765
Watch next: Playlist Vasopressors and Inotropes:
https://youtube.com/playlist?list=PLf5bMa9_tvRg_nAnm91hsyHhI0y_ahoS1&si=Myz25vHJgHAp4Nvc

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COLLECTION OF PLAYLISTS:

Critical Care Medicine 🚑
https://youtube.com/playlist?list=PLf5bMa9_tvRiZ85NNUGwk91YpqDWdIGvA&si=jGyrxrOcvQqTldFb

Pulmonology🫁
https://youtube.com/playlist?list=PLf5bMa9_tvRinTHdWwKFYBX7N5kfOBRHz&si=BKliNG26xrQqUNvx

Cardiology and ECG🫀
https://youtube.com/playlist?list=PLf5bMa9_tvRh2JoODgpLapjGDYXSW1q0h&si=jnr41duxoNnMw4ss

Nephrology🧂
https://youtube.com/playlist?list=PLf5bMa9_tvRgwXdcj18ux70r08Et93idU&si=tbOHFsPfZgFFZxWg

Acid Base🧬
https://youtube.com/playlist?list=PLf5bMa9_tvRjj4NDR0eq6M6TqKiZQZChX&si=iC0eBYNRCawR7f0G

Medical, Healthcare, and Science News📰
https://youtube.com/playlist?list=PLf5bMa9_tvRhsj4rBQzF7YOtboBoHL2u9&si=OBt6z2aJabzPoLeR

Biostatistics and Research📊
https://youtube.com/playlist?list=PLf5bMa9_tvRikRVVVVL09H-GxxrlJiZJh&si=vUO_j8D3VPqGAIAl

Immunology🧫
https://youtube.com/playlist?list=PLf5bMa9_tvRjLvJPC2ub_mLSxFmL7dNnt&si=RmbzEewJV1YU3PEx

Laboratory Evaluation and Values🧪
https://youtube.com/playlist?list=PLf5bMa9_tvRjGho7xcGieA1Hdkaj4vCCF&si=6cEOyuA8wuKcdpbp

Infectious Disease🦠
https://youtube.com/playlist?list=PLf5bMa9_tvRj4G9ApK7nw-7V2Ye31_MR9&si=C-_5_1x7RXrzaTMs

Obstetrics and Gynecology👶
https://youtube.com/playlist?list=PLf5bMa9_tvRgYRUdsBVEZ345SY0yYVEl9&si=A0SYAeK637NiMIdu

Procedures💉
https://youtube.com/playlist?list=PLf5bMa9_tvRiUYMZbBl-KBJJe2vyoeWyL&si=WJzDSnFd049JgHDc

Endocrinology🎂
https://youtube.com/playlist?list=PLf5bMa9_tvRgxyOVpxlkKAxsx4mtr6nGx&si=eiLnS5kDySGdHxMP

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DISCLAIMER THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.

#Hydroxocobalamin #Vasopressor #Vasoplegia #ShockManagement #CriticalCare #ICUPharmacology #CyanidePoisoning #NOScavenger #VitaminB12 #CatecholamineResistantShock #USMLE #MedicalEducation

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