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verapamil
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• 08/28/25
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Side Effects
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A non-dihydropyridine voltage-dependent calcium channel blocker (class-IV antiarrhythmic agent) used to treat supraventricular tachycardia, high blood pressure, and angina pectoris. It may also be used for prevention of migraines and cluster headaches. It is given by mouth or intravenously.
It is also a voltage-gated potassium (Kv) channel.
(Location of calcium channels: Actions of the drug.)
• Sinoatrial and atrioventricular nodes (SA node and AV node): It decreases conduction of the impulse through the AV node, thus protecting the ventricles from supraventricular tachycardia.
• Smooth muscles lining blood vessels: By relaxing the tone of smooth muscles, it dilates the blood vessels treating high blood pressure and angina pectoris. The pain of angina is caused by a deficit in oxygen supply to the heart, and it increases the blood supply to the heart.
(Common side effects)
• low blood pressure
• headache
• dizziness
• nausea
• constipation
(Other side effects include)
• allergic reactions
• muscle pains
• gingival enlargement
etc.
(Contraindication)
• hypotension
• bradycardia
• left ventricular heart failure
• pre-excitation syndromes
• atrial flutter
• atrial fibrillation
etc.
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