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What's Wrong with Strattera?

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Main Chapters:
00:00 Intro - What's Wrong with Strattera?
00:10 Take home message
00:59 History of Strattera
03:33 Strattera compared to Alternatives
10:51 Effects of Strattera for ADHD
12:06 Side effects of Strattera
17:34 Study comparing Strattera and Qelbree
21:24 Conclusion
22:27 Questions

The FDA approved Strattera (atomoxetine) two decades ago as the first non-stimulant for the treatment of ADHD. Although designed with the hope of being an effective antidepressant, it had more clearcut results for ADHD. But from the beginning, many, many people haven’t responded well to the medication. It seems to take a long time to work, and lots of people have troubling side effects. And that’s not just in comparison to stimulants. A recent head to head comparison with another non-stimulant for ADHD, Qelbree (viloxazine) found that Strattera was less effective, had more side effects, and took longer to provide benefits.

If Strattera is working for you, great, keep taking it. But if your response is mediocre or worse, there are several other non-stimulants that might help you more, including Qelbree, Wellbutrin, guanfacine, and even Cymbalta (duloxetine).

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References:
Extended-Release Viloxazine Compared with Atomoxetine for Attention Deficit Hyperactivity Disorder (2023)
https://link.springer.com/arti....cle/10.1007/s40263-0

Atomoxetine in patients with ADHD: A clinical and pharmacological review of the onset, trajectory, duration of response and implications for patients
https://journals.sagepub.com/d....oi/10.1177/026988111

The Effect of Methylphenidate and Atomoxetine on Heart Rate and Systolic Blood Pressure in Young People and Adults with Attention-Deficit Hyperactivity Disorder (ADHD): Systematic Review, Meta-Analysis, and Meta-Regression
https://www.mdpi.com/1660-4601/15/8/1789

Full Chapter list:
00:00 Intro - What's Wrong with Strattera?
00:10 Take home message
00:59 History of Strattera
03:33 Strattera compared to Alternatives
04:31 Strattera Receptor Binding Data
06:02 Cymbalta / Qelbree / Wellbutrin
07:46 Ritalin / Reboxetine / Paxil
09:03 Strattera in Live Animals and Humans
10:51 Effects of Strattera for ADHD
12:06 Side effects of Strattera
14:06 Suicidality / Blood Pressure / Heart Rate
16:00 Drug Interactions / Dosage
17:34 Study comparing Strattera and Qelbree
19:50 Study Analysis
21:24 Conclusion
22:27 Questions
22:43 Side effects of Adderall and Alteranatives
23:38 Is Cymbalta working on Dopamine?
24:27 Modafinil for ADHD
26:58 Medication Risks of Panic attacks and Addiction
28:57 Guanfacine for ADHD
29:43 Amphetamine vs Methylphenidate
30:41 Outro

Streamed live October 4, 2023

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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world.

Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background.

You're welcome to email him with topics you want discussed or people you think he should interview.

[email protected]

#health #mentalhealth #adhd #strattera

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