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What Is Ondansetron? | Indications | Dose Form | Contraindications | Side Effects | Brand Name
What is Ondansetron? Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also effective for treating gastroenteritis. It can be given by mouth or by injection into a muscle or into a vein.
Side Effects of Ondansetron, Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness. Serious side effects include QT prolongation and severe allergic reaction. It appears to be safe during pregnancy but has not been well studied in this group. It is a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic receptors.
Ondansetron was patented in 1984 and approved for medical use in 1990.[8] It is on the World Health Organization's List of Essential Medicines.[9] It is available as a generic medication.[4] In 2019, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions.
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