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Xenical: effective weight loss medication or a sh*tty alternative?
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• 08/28/25
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Xenical or orlistat, the generic name, is what we call a lipase inhibitor. When it comes to our digestion system, in order for our body to absorb nutrients from the food we eat, it needs to break food down into its smallest components.
A lipase inhibitor like Xenical does just as the name implies - it inhibits lipase, an enzyme that helps to break down fats. If fats are not broken down they are not absorbed, therefore reducing the number of calories our body takes up!
⚠️ But is it as easy as it sounds? Let’s take a look!
References:
- Torgerson, J. S., Hauptman, J., Boldrin, M. N. & Sjöström, L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 27, 155–161 (2004).
- Davidson, M. H. et al. Weight Control and Risk Factor Reduction in Obese Subjects Treated for 2 Years With Orlistat: A Randomized Controlled Trial. JAMA 281, 235–242 (1999).
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