About ISOSORBIDE DINITRATE
ISOSORBIDE DINITRATE belongs to the class of blood pressure-lowering medications called ‘nitrate vasodilators’ used in the prevention of angina (heart-related chest pain) or heart failure. Angina pectoris (angina) is chest pain occurring due to reduced blood flow to the heart (coronary artery disease). It occurs when the blood vessels supplying the heart are blocked or narrowed.
ISOSORBIDE DINITRATE contains ‘isosorbide dinitrate’ which works by dilating, relaxing, and widening the constricted blood vessels, thereby increasing the blood and oxygen supply to the heart. Thus, it effectively helps prevent the risk of future heart attack and stroke in the future, especially in high blood pressure patients.
Do not take it if you are allergic to ‘isosorbide dinitrate’ or any ingredients of it. Do not use in patients with severe heart failure, severe hypotension (low blood pressure), bleeding in the brain, severe dehydration, heart valve problems, progressive heart failure due to chronic lung disease, severe anemia (low levels of iron), and severe hypoxemia (low levels of oxygen in the blood). Inform your doctor if you have an underactive thyroid gland, glaucoma (an eye condition), or head injury. Inform your doctor if you are taking other prescription or non-prescription medicines, especially medicines used to treat erectile dysfunction in men. ISOSORBIDE DINITRATE contains lactose, so inform your doctor if you have an intolerance to some sugars. Also, inform your doctor if you are pregnant or breastfeeding.
Uses of ISOSORBIDE DINITRATE
Angina (heart related chest pain)
Medicinal Benefits
ISOSORBIDE DINITRATE contains ‘isosorbide dinitrate’ which is a ‘nitrate’ and a vasodilator. It acts by dilating and relaxing the constricted blood vessels due to increased blood pressure (hypertension). This effect helps in improving the blood and oxygen supply to the heart, thus decreasing the risk of angina or heart-related chest pain. Thus, ISOSORBIDE DINITRATE prevents the risk of chest pain in heart conditions like coronary artery disease.
Side Effects of ISOSORBIDE DINITRATE
• Headache
• Flushing (redness of the skin, especially the face)
• Low blood pressure
• Dizziness
In-Depth Precautions and Warning
Drug Warnings
Do not take ISOSORBIDE DINITRATE if you are allergic to ‘isosorbide dinitrate’ or its contents. Do not take it if you have severe low blood pressure, bleeding or increased pressure in the brain, severe dehydration, heart valve problems, inflammation of the heart wall, high blood pressure due to long-term lung disease, and severe anemia. Before taking ISOSORBIDE DINITRATE, inform your doctor if you have glaucoma (increased pressure in the eye), glucose 6 phosphate dehydrogenase deficiency (a type of anemia), underactive thyroid (hypothyroidism), kidney or liver problems, head injury, hypothermia (low body temperature), or intolerance to some sugars. This medicine should not be used with medicines used for erectile dysfunction like sildenafil or tadalafil. Inform your doctor if you are pregnant or breastfeeding.
Drug Interactions
Drug-Drug interactions: ISOSORBIDE DINITRATE should not be used with organic nitrate drugs used to treat erectile dysfunction (sildenafil, vardenafil, tadalafil, and avanafil) and medicine used to treat pulmonary hypertension (riociguat), medicines to treat high blood pressure (norepinephrine), phenothiazines, and antiallergic medications.
Drug-Food interactions: Intake of foods containing high amounts of sodium should be reduced.
Drug-Disease interactions: ISOSORBIDE DINITRATE use is contraindicated in conditions such as acute myocardial infarction or congestive heart failure, severe hypotension (low blood pressure), severe anemia, bleeding in the brain, and severe dehydration.
Drug-Drug Interactions Checker List:
• TADALAFIL
• SILDENAFIL
• VARDENAFIL
• AVANAFIL
• RIOCIGAUT
• NOREPINEPHRINE

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