Peter L. Salgo, MD; Jason Pogue, PharmD, BCPS-AQID; and Andrew Shorr, MD, discuss the recent approval of Vabomere, a combination of meropenem and vaborbactam, in the setting of gram-negative nosocomial infections based on the positive study results of the TANGO II trial.

Meropenem is a broad-spectrum carbapenem antibiotic used to treat a variety of bacterial infections. Here are some key points about its pharmacology:

Mechanism of Action
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which inhibits the final transpeptidation step of peptidoglycan synthesis. This leads to bacterial cell lysis due to ongoing activity of cell wall autolytic enzymes2.

Spectrum of Activity
Meropenem is effective against a wide range of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus (methicillin-susceptible isolates), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species.

Pharmacokinetics
Absorption: Administered intravenously or intramuscularly.

Distribution: Penetrates into most tissues and body fluids, including the urinary tract, peritoneal fluid, bone, bile, lung, bronchial mucosa, muscle tissue, and heart valves.

Metabolism: Not extensively metabolized; primarily excreted unchanged by the kidneys.

Elimination: The elimination half-life is approximately 1 hour in adults, but this can vary depending on renal function.

Protein Binding: Approximately 2%.

Dosage and Administration
Adults: Typically, the dose is 1 gram IV every 8 hours, not to exceed 2 grams IV every 8 hours.

Children: Dosage is adjusted based on body weight and renal function.

Neonates and Infants: Dosage is also adjusted based on body weight and renal function.

Side Effects
Common side effects include gastrointestinal disturbances (nausea, vomiting, diarrhea), allergic reactions, and injection site reactions. Rarely, it can cause nephrotoxicity and ototoxicity1.

Drug Interactions
Meropenem can interact with other nephrotoxic drugs, increasing the risk of kidney damage. It should be used cautiously with medications that affect renal function1.

Indications
Meropenem is indicated for the treatment of various infections caused by susceptible bacteria, including complicated skin and skin structure infections, intra-abdominal infections, and bacterial meningitis
#Meropenem

Meropenem Dose adjustment in Renal failure or
Meropenem Dose adjustment in kidney impairment - Pharmacology

In this video, we will discuss the dose adjustment of Meropenem based on serum creatinine levels using the Cockcroft-Gault Formula. Meropenem is a commonly used antibiotic, and it is crucial to ensure the appropriate dose is administered to avoid adverse effects and ensure optimal efficacy.

We will take an example of a male patient and refer to the Lexicomp and Micromedex recommendations for the appropriate Meropenem dose based on his creatinine clearance. Both referencing resources recommend the same dosage adjustment for Meropenem.

If you want to learn how to estimate creatinine clearance using the Cockcroft-Gault formula, and determine the appropriate dosage for medications eliminated by the kidneys, such as Meropenem, then this video is for you!

Keywords: Meropenem, dose adjustment, serum creatinine, Cockcroft-Gault Formula, Lexicomp, Micromedex, dosage guidelines, creatinine clearance, antibiotics, adverse effects, efficacy.

Evidence linked at pharmacyjoe.com/episode572

The Power of Meropenem Injection | Effective Uses in Hindi

In this video, we'll be discussing the powerful antibiotic meropenem, its uses in Hindi, and some of the potential side effects associated with its use.
If you're looking for an effective antibiotic to treat infections, be sure to watch this video! We'll discuss the uses of meropenem in Hindi, as well as some of the potential side effects associated with its use. By the end of this video, you'll know everything you need to know about this powerful antibiotic!
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Meropenem Tablet | Meropenem injection | Uses | Doses | Side Effects

Some Facts about Meropenem Injection #meropeneminjection #meropenem #carbapenem

In this video it is described that
MEROPENEM is a carbapenem antibiotic. It treats some infections caused by bacteria. It will not work for colds, the flu, or other viruses.
COMMON BRAND NAME: Merrem
Precautions:
brain tumor
kidney disease
seizures
an unusual or allergic reaction to meropenem, other antibiotics or medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How to use this medication?
This drug is injected into a vein. It is usually given by a health care provider in a hospital or clinic setting.
If you get this drug at home, you will be taught how to prepare and give it.
Use exactly as directed.
Take it as directed on the prescription label at the same time every day. Keep taking it unless your health care provider tells you to stop.
It is important that you put your used needles and syringes in a special sharps container.
Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or health care provider to get one.
Talk to your health care provider about the use of this drug in children. While it may be prescribed for children as young as newborns for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medication?
birth control pills
probenecid
valproic acid
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use.
What should I watch for while using this medication?
Your condition will be monitored carefully while you are receiving this medicine. Tell your doctor or health care provider if your symptoms do not start to get better or if they get worse.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.
Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.
What side effects may I notice from receiving this medication?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bloody or watery diarrhea
fever
fever with rash, swollen lymph nodes, or swelling of the face
pain, redness, or irritation at site where injected
pain, tingling, numbness in the hands or feet
rash, fever, and swollen lymph nodes
redness, blistering, peeling or loosening of the skin, including inside the mouth
seizures
unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
constipation
diarrhea
dizziness
headache
nausea, vomiting
stomach pain
vaginal discharge, itching, or odor in women
Where should I keep my medication?
Keep out of the reach of children and pets.

Meropenem Injection Uses, Mechanism of Action & Doses In Hindi | Menem 1g

Hi Friends Welcome To Gyanear The Medical Channel I Am Pharmacist Shivam Vishwakarma
About This Video: is video me meri lene injection ke bare me bataya hai ki ye kya hai kis bimari me lagate hai kya mechanism of action hai or kya side effects jane ki merken ya mene ka dose kya hota hai



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Disclaimer:All information is based on the data collected,consult a doctor before using any medication.
Some Contents Are Used For Educational Purpose Under Fair Use. 

About : Gyanear Is An Medical Channel In Hindi,Here We Provide Medical Knowledge About Disease, Treatment,Medical Procedure, Allopathy Drugs For Medical Student And Comman Man

Ryan K. Shields, PharmD, MS, reacts to research presented at IDWeek 2019 on cefiderocol versus high-dose meropenem for patients with nosocomial pneumonia.

Meromac injection Use Dose Side effects and Price explained in Hindi. How Meropenem Antibiotic works and its role in bacterial infection explained.

Meromac 1gm Injection is an antibiotic that is used to treat severe infections of the skin lungs stomach urinary tract blood and brain.
It works by killing the bacteria that cause these problems.

#meromacinjection #meropenem #antibiotics #infection #meromacinjectionuse

Welcome to MediInsights, your go-to destination for comprehensive medical knowledge and insights. In this video, we delve into the world of Meropenem Injection, a critical antibiotic used in the treatment of severe bacterial infections. Join us as we unlock the intricacies of Meropenem, exploring its dosage, mechanism of action, potential side effects, and crucial advice for its safe use.

Meropenem Injection is a potent medication often reserved for serious infections where other antibiotics may not be effective. Understanding its proper dosage is essential for effective treatment. We'll provide detailed information on recommended dosages for various infections, ensuring that healthcare professionals and patients alike have the knowledge they need to administer this medication safely and effectively.

Furthermore, we'll unravel the mechanism of action behind Meropenem Injection, shedding light on how this antibiotic works to combat bacterial infections. By inhibiting bacterial cell wall synthesis, Meropenem effectively targets and destroys harmful bacteria, offering a powerful weapon against a wide range of pathogens.

However, like all medications, Meropenem Injection may come with potential side effects. From nausea and vomiting to allergic reactions, we'll explore the common and rare side effects associated with this antibiotic. Understanding these side effects is crucial for both patients and healthcare providers to recognize and address any adverse reactions promptly.

Lastly, we'll provide important advice for using Meropenem Injection safely. From completing the full course of treatment to communicating any allergies or medical conditions to healthcare providers, we'll cover essential tips to ensure the optimal and safe use of this medication.

At MediInsights, we believe in unlocking the wonders of wellness through knowledge and understanding. Join us on this journey as we empower you with valuable insights into Meropenem Injection, equipping you with the information you need to make informed decisions about your health and well-being. Don't forget to like, share, and subscribe for more enlightening content on healthcare and medicine. Thank you for watching!

Disclaimer: This video is intended for educational and informational purposes only. The content provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or the use of medications. The information presented here is based on general knowledge and research and may not be applicable to individual circumstances. The creators of this video do not endorse or promote any specific medical products or treatment regimens. Viewers are encouraged to consult their healthcare provider for personalized medical advice. The content provided in this video complies with YouTube's community guidelines and policies.

CHAPTERS:
0:00 :INTRO
0:43 :USE OF METFORMIN TABLETS
1:15 :DOSAGE OF METFORMIN TABLETS
2:00 :MECHANISM OF ACTION OF METFORMIN TABLETS
2:25 :SIDE EFFECTS OF METFORMIN TABLETS
2:57 :IMPORTANT ADVICES FOR USING METFORMIN TABLETS


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#MedicationDosage
#MechanismOfAction
#DrugSafety
#Healthcare
#WellnessTips
#MedicalAdvice
#SideEffects
#TreatmentGuidelines
#PatientEducation
#InfectiousDiseases
#Pharmacology
#HealthEducation
#AntibioticResistance
#MedicalScience
#IntravenousMedication
#DrugInteractions

Meropenem Inj 1gm Use Dose Side Effects and Price explained here in Hindi)

Meropenem is used in severe bacterial infections. It is used in infections of various body parts like skin and soft tissues urinary tract blood brain and lungs (pneumonia).
How Meropenem works
Meropenem is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Common side effects of Meropenem
Rash Headache Vomiting
Nausea Diarrhea and Injection site inflammation



#meropenem #meropeneminjection #antibiotic #meropenemsideeffects #meropenemuse

Meropenem side effects 💊 - what is meropenem used for

Meropenem is a broad spectrum antibiotic belongs to beta-lactam class.
Meropenem is only available in injection form. Meropenem injection is administered to I.V. route only.
Meropenem injection is available in different strength such as
Meropenem 250 mg injection
Meropenem 500 mg injection
Meropenem 1000gm injection | Meropenem 1g injection

Meropenem injection brand name are
1. Meromac injection | meromac 1g
2. Menem injection
3. Mero injection
4. Meropenia injection
5. Meronem injection

Meropenem is used in the treatment of severe bacterial infections like:-
1. Meningitis
2. Intra-abdominal infection
3. Pneumonia
4. Anthrex
5. Sepsis and many other bacterial infection which are not listed

Meropenem injection common dose is 10 mg-40 mg / kg/ 8hours for adult.
Meropenem injection side effects are
1. Skin allergic reactions
2. Hypersensitivity reactions
3. Skin rashes
4. Nausea, vomiting
5. Constipation, diarrhoea
6. Headache, abdominal upset and many other which are not listed

We also discuss about meropenem iv injection
Brand name
Uses in detail
Dosage
How to administer
Side effects in Hindi

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Meropenem

Meropenem is a broad-spectrum antibiotic medication that belongs to the class of drugs known as carbapenems. It is commonly used to treat various types of severe bacterial infections caused by gram-negative and gram-positive bacteria. Meropenem is considered a powerful and effective antibiotic, often used when other antibiotics have failed or when the specific bacteria causing the infection are unknown.

It works by inhibiting the synthesis of bacterial cell walls, leading to the death of the bacteria. This mechanism of action makes meropenem effective against a wide range of bacteria, including those resistant to other types of antibiotics.

Meropenem is administered intravenously (IV) by a healthcare professional and is typically prescribed for serious infections like pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and sepsis. The dosage and duration of treatment depend on the severity of the infection, the patient's condition, and other factors.

Common side effects of meropenem may include diarrhea, nausea, vomiting, headache, and pain or swelling at the injection site. More serious side effects, although rare, may include allergic reactions, seizures, and changes in kidney function. It is important to follow the healthcare provider's instructions and complete the full course of treatment even if the symptoms improve.

As with any medication, it's essential to inform your doctor of any medical conditions, allergies, or other medications you are taking before starting meropenem to avoid potential interactions or complications.