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Antidepressants: SSRI, SNRI & Tricyclic Antidepressatns. Citalopram Prozac Amitriptyline Side Effects 1 Views • 13 days ago

SKIP AHEAD:
2:20 – Mechanism of Antidepressants
3:16 – General Principles of Antidepressant Use: Suicide, Mania & Serotonin Syndrome
7:51 – Tricyclic Antidepressants
9:10 – TCA Side Effects
10:40 – SSRIs
11:47 – SSRI Side Effects
13:01 - SNRIs
13:33 – Atypicals: Bupropion, Mirtazapine & Trazadone

Antidepressant mechanism - One hypothesis for the pathophysiology of depression is that it is due to low levels of monoamine neurotransmitters (mainly serotonin, norepinephrine and dopamine). That is why antidepressants aim to increase the levels of these neurotransmitters in the synaptic cleft. They do this by slowing the reuptake of the neurotransmitters so that they stay in the cleft longer and interact with post synaptic receptors more often. The first drugs in this group were non-specific and increased all of the monoamines, which lead to lots of side effects and safety issues related to toxicity. Newer antidepressants are more selective and mostly only effect 1 or 2 monoamines.

General principles:
Unfortunately, antidepressants take at least a month to start working. Good patient education about the delayed onset of effect and close monitoring of the patient during this initial period is extremely important. Patients can become hopeless if they expect the drug to start working right away. This may be one reason why antidepressants are associated with suicide, especially in patients 25 years old and younger. Another proposed mechanism is that a depressed person may have the energy to carry out their suicide once the medications start to work. There is now a black box warning for suicide on antidepressants. Some psychiatrists argue that they don’t actually see this association with suicide in clinical practice, and that the thing that really increases the risk for suicide is not treating a depressed person with the proper medications. However, it is still standard practice to have a close follow up with patients you are starting on antidepressants. Usually this will involve a follow up visit about 2 weeks after the medication is started. At this visit the drug will not have started working yet so you can’t evaluate efficacy, but you can monitor for side effects like suicidality. Another serious side effect you have to be on the lookout for soon after initiating treatment is mania. If a bipolar individual is incorrectly diagnosed as having depression, an antidepressant may induce a manic episode.

Another very serious side effect that has to be considered for antidepressants is Serotonin Syndrome. This usually occurs when you combined multiple antidepressants at the same time or combine an antidepressant with another medication that increases serotonin such as dextromethorphan or an opioid. It presents with tremor, diaphoresis, tachycardia, flushing and hypertension. If not corrected it can progress to delirium, AMS and death. Treatment includes medication cessation and the use of Cyproheptadine (a serotonin antagonist). In order to prevent this from happening you should have about a month “Wash Out” period when you are switching between antidepressants. So you taper the 1st medication down and then stop it, give the patient at least a month with no antidepressant and then start adding the new medication slowly.

Most side effects begin immediately after starting the medication, but diminish over the course of a month. This is another reason why patient compliance is poor with these meds. It makes them sick and the drug doesn’t work during the first few weeks. However, if they can stick with it the medications will likely start working and the side effects will diminish over time. A principle that applies to all of the antidepressants is “start low and go slow.” This means that you start with a lower dose and slowly increase it in order to decrease side effects and increase patient compliance. The dose you start the patient on may not even be at a therapeutic level, but every month or so you can increase the dose a bit.

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Pictures Used:
• “SynapseSchematic” by Thomas Splettstoesser available at https://commons.wikimedia.org/....wiki/File:SynapseSch via Creative Commons 4.0 Attribution-Share Alike
• “Zoloft Bottles” by Ragesoss available at https://commons.wikimedia.org/....wiki/File:Zoloft_bot via Public Domain

Tricyclic Antidepressants: Therapies - Psychiatric Mental Health for Nursing Students | @LevelUpRN Side Effects 0 Views • 13 days ago

Cathy discusses tricyclic antidepressants, including amitriptyline and imipramine. She covers the indications, mode of action, side effects, and patient teaching associated with this medication class.

Cathy Parkes BSN, RN, CWCN, PHN covers Psychiatric Therapies: Tricyclic Antidepressants. The Psychiatric Mental Health Therapies video tutorial series is intended to help RN and PN nursing students study for your nursing school exams, including the ATI, HESI and NCLEX.

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00:00 What to expect - Tricyclic Antidepressant
00:24 Indications and Mode of Action of Tricyclic Antidepressants
00:49 Tricyclic Antidepressant Side Effects
1:45 Patient Teaching for Tricyclic Antidepressants
2:12 Quiz Time!

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ECOTRIN - Brand Names, How to use, and Side Effects. Side Effects 0 Views • 13 days ago

Using Your Prefilled Pen | Ebglyss™ (lebrikizumab-lbkz) 250 mg/2mL injection Side Effects 0 Views • 13 days ago

#Ebglyss #EbglyssInjection #PreFilledPen
INDICATION AND SAFETY SUMMARY
EBGLYSS™ (EHB-glihs) is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) with moderate-to-severe eczema (atopic dermatitis) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).

WARNINGS - DO NOT USE EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

BEFORE USING
BEFORE USING EBGLYSS, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL YOUR MEDICAL CONDITIONS, INCLUDING IF YOU:
☐ Have a parasitic (helminth) infection.
☐ Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
☐ Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
☐ Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

TELL YOUR HEALTHCARE PROVIDER ABOUT ALL THE MEDICINES YOU TAKE, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

POSSIBLE SIDE EFFECTS
EBGLYSS CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING:
• ALLERGIC REACTIONS. EBGLYSS CAN CAUSE ALLERGIC REACTIONS THAT MAY SOMETIMES BE SEVERE. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
◦ breathing problems or wheezing
◦ swelling of the face, lips, mouth, tongue or throat
◦ hives
◦ itching
◦ fainting, dizziness, feeling lightheaded
◦ skin rash
◦ cramps in your stomach area (abdomen)
• EYE PROBLEMS. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

THE MOST COMMON SIDE EFFECTS OF EBGLYSS INCLUDE:
• eye and eyelid inflammation, including redness, swelling, and itching
• injection site reactions
• shingles (herpes zoster)

THESE ARE NOT ALL OF THE POSSIBLE SIDE EFFECTS OF EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

HOW TO TAKE
• SEE THE DETAILED “INSTRUCTIONS FOR USE” THAT COMES WITH EBGLYSS FOR INFORMATION ABOUT HOW TO PREPARE AND INJECT EBGLYSS AND HOW TO PROPERLY STORE AND THROW AWAY (DISPOSE OF) USED EBGLYSS PREFILLED PENS AND PREFILLED SYRINGES.
• Use EBGLYSS exactly as prescribed by your healthcare provider.
• EBGLYSS is given as an injection under the skin (subcutaneous injection).
• If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
• If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

LEARN MORE
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to EBGLYSS.LILLY.COM

This summary provides basic information about EBGLYSS but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking to your doctor. Be sure to talk to your doctor or other healthcare provider about EBGLYSS and how to take it. Your doctor is the best person to help you decide if EBGLYSS is right for you.

LK CON BS AD APP

EBGLYSS™ and its delivery device base are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

EBGLYSS™ Indication and Safety Summary Side Effects 0 Views • 13 days ago

Please see FULL PRESCRIBING INFORMATION at https://e.lilly/ebglyssPI , including Patient Information at https://e.lilly/ebglyssPPI and Instructions for Use at https://e.lilly/ebglyssIFU , for EBGLYSS.

INDICATION AND SAFETY SUMMARY

EBGLYSS™ (EHB-glihs) is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) with moderate-to-severe eczema (atopic dermatitis) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).

WARNINGS – DO NOT USE EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

BEFORE USING
BEFORE USING EBGLYSS, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL YOUR MEDICAL CONDITIONS, INCLUDING IF YOU:
• Have a parasitic (helminth) infection.
• Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
• Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
• Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

TELL YOUR HEALTHCARE PROVIDER ABOUT ALL THE MEDICINES YOU TAKE, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

POSSIBLE SIDE EFFECTS
EBGLYSS CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING:
• ALLERGIC REACTIONS. EBGLYSS CAN CAUSE ALLERGIC REACTIONS THAT MAY SOMETIMES BE SEVERE. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
o breathing problems or wheezing
o swelling of the face, lips, mouth, tongue or throat
o hives
o itching
o fainting, dizziness, feeling lightheaded
o skin rash
o cramps in your stomach area (abdomen)
• EYE PROBLEMS. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

THE MOST COMMON SIDE EFFECTS OF EBGLYSS INCLUDE:
• eye and eyelid inflammation, including redness, swelling, and itching
• injection site reactions
• shingles (herpes zoster)

THESE ARE NOT ALL OF THE POSSIBLE SIDE EFFECTS OF EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

HOW TO TAKE
• SEE THE DETAILED “INSTRUCTIONS FOR USE” THAT COMES WITH EBGLYSS FOR INFORMATION ABOUT HOW TO PREPARE AND INJECT EBGLYSS AND HOW TO PROPERLY STORE AND THROW AWAY (DISPOSE OF) USED EBGLYSS PREFILLED PENS AND PREFILLED SYRINGES.
• Use EBGLYSS exactly as prescribed by your healthcare provider.
• EBGLYSS is given as an injection under the skin (subcutaneous injection).
• If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
• If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

LEARN MORE
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com

This summary provides basic information about EBGLYSS but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking to your doctor. Be sure to talk to your doctor or other healthcare provider about EBGLYSS and how to take it. Your doctor is the best person to help you decide if EBGLYSS is right for you.

LK CON BS AD APP

EBGLYSS™ and its delivery device base are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Trulicity injection | GLP1 agonists| Dulaglutide| Trulicity what does it do | Trulicity full Review Side Effects 2 Views • 13 days ago

Dr. Asif khan a qualified Pharmacist is providing medical information to you in a very simple way so to watch other videos lectures of him click on the below links :

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#trulicity