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RIFAXIMIN. Mechanism of Action. Side effects. Side Effects 4 Views • 5 months ago

0:00 Overview of Rifaximin
0:26 Why Gastrointestinal selective
1:20 Why so safe ( no side effects)
2:32 Bactericidal activity
3:26 Molecular mechanism of action ( DNA-dependent RNA polymerase)
6:15 Indications ( Travellers diarrhea. SIBO. Cirrhosis. IBS)
8:12 Clinical mechanism of action
9:34 Why can’t kill invasive bacteria (contraindications)

Article review.
DuPont, H. L. (2011). Biologic properties and clinical uses of rifaximin. Expert opinion on pharmacotherapy, 12(2), 293-302.
DuPont, H. L. (2015, August). Therapeutic effects and mechanisms of action of rifaximin in gastrointestinal diseases. In Mayo Clinic Proceedings (Vol. 90, No. 8, pp. 1116-1124). Elsevier.
Koo HL, DuPont HL. Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases. Curr Opin Gastroenterol. 2010;26(1):17-25. doi:10.1097/MOG.0b013e328333dc8d
Shayto RH, Abou Mrad R, Sharara AI. Use of rifaximin in gastrointestinal and liver diseases. World J Gastroenterol. 2016 Aug 07;22(29):6638-51.
Bruzzese E, Pesce M, Sarnelli G, Guarino A. Pharmacokinetic drug evaluation of rifaximin for treatment of diarrhea-predominant irritable bowel syndrome.
Scarpignato C, Pelosini I. Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential. Chemotherapy. 2005;51 Suppl 1:36-66.
Gatta L, Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017 Mar;45(5):604-616.

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Does Brexpiprazole (Rexulti) Cause Weight Gain? - Schizophrenia Support Network Side Effects 3 Views • 5 months ago

Does Brexpiprazole (Rexulti) Cause Weight Gain? In this informative video, we will discuss Brexpiprazole, commonly known as Rexulti, and its effects on weight for individuals undergoing treatment for schizophrenia. This second-generation antipsychotic is often prescribed to help manage symptoms, but like many medications in this category, it can lead to weight changes. We will review clinical findings regarding weight gain associated with Brexpiprazole, including average increases during both short-term and long-term treatment periods.

Additionally, we will explore the mechanisms behind these weight changes, including how the medication interacts with brain receptors that influence appetite and metabolism. We will also touch on the importance of monitoring weight and metabolic health while on this medication, as well as the potential impact of weight gain on treatment adherence and overall health.

Understanding the balance between managing schizophrenia symptoms and addressing side effects is essential for patients and healthcare providers alike. Join us for this thorough discussion, and make sure to subscribe to our channel for more helpful information about schizophrenia and its treatment options.

⬇️ Subscribe to our channel for more valuable insights.

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#Brexpiprazole #Rexulti #WeightGain #Schizophrenia #MentalHealth #Antipsychotics #MedicationSideEffects #Neurotransmitters #Healthcare #PatientSupport #MentalHealthAwareness #TreatmentOptions #WeightManagement #MedicationMonitoring #MentalHealthResources

About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

REXULTI - -- Generic Name , Brand Names, Precautions , How to use, Side Effects Side Effects 3 Views • 5 months ago

Rexulti | The First FDA Approved Drug for Dementia-Related Agitation Side Effects 5 Views • 5 months ago

🧠 Are you seeking information on managing agitation in dementia, particularly Alzheimer's disease? Welcome to our video "Rexulti | The First FDA Approved Drug for Dementia-Related Agitation" This video provides a comprehensive overview of Rexulti (brexpiprazole), a newly approved medication for treating agitation associated with Alzheimer's dementia.

➡️ In This Video: We'll explore the challenges of agitation in Alzheimer's, the limitations of past treatments, and how Rexulti emerges as a promising option. Learn about its effectiveness, dosage, potential side effects, and important considerations for those caring for someone with dementia.

🔍 What You'll Learn:
The Impact of Agitation in Alzheimer's Disease

Historical Treatments for Dementia-Related Agitation
Introduction to Rexulti (brexpiprazole) for Alzheimer's Agitation
FDA Approval and Clinical Study Insights
Recommended Dosages and Administration
Side Effects and Safety Precautions

🌟 Why Watch? This video is essential for caregivers, family members, and anyone involved in the care of individuals with Alzheimer's experiencing agitation. It offers valuable insights into modern treatment options and helps you understand the benefits and risks associated with Rexulti.

👉 Subscribe for More Health Information: Stay updated with the latest in dementia care and treatment options. We release new informative videos regularly. Subscribe now to not miss out on valuable health insights!

🔗 Recommended Resources: Check the description below for links to additional information on Alzheimer's care, Rexulti, and other related treatments.

📚 Stay Informed, Stay Compassionate: Remember, managing dementia requires understanding, patience, and informed decisions. Always consult with healthcare professionals before starting any new treatment. Empower yourself with knowledge to provide the best care possible.

👍 Like, Share, and Comment: If this video was helpful, please give it a thumbs up, share it with others who might benefit, and leave a comment below with your thoughts or experiences.

📩 Contact Us: For further information or inquiries, please contact us at [Your Email/Contact Information].

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What Are The Long-Term Effects Of Brexpiprazole (Rexulti)? - Schizophrenia Support Network Side Effects 2 Views • 5 months ago

What Are The Long-Term Effects Of Brexpiprazole (Rexulti)? In this informative video, we will discuss the long-term effects of brexpiprazole, also known as Rexulti, for individuals living with schizophrenia. As a second-generation antipsychotic, brexpiprazole plays a crucial role in managing various symptoms associated with this condition. We will cover how this medication can lead to improvements in both positive symptoms, like hallucinations and delusions, and negative symptoms, such as social withdrawal and lack of motivation.

Additionally, we will explore how brexpiprazole can enhance overall functioning in daily life. Many patients experience better personal relationships, improved self-care, and greater engagement in daily activities as their symptoms improve. We will also touch on the side effects associated with this medication, including common issues like weight gain and movement disorders, and how they compare to other antipsychotics.

For those living with schizophrenia, understanding the potential benefits and side effects of brexpiprazole is essential for making informed decisions about treatment options. Join us as we break down this important topic and provide insights that can help improve quality of life for individuals affected by this condition. Don't forget to subscribe to our channel for more helpful information on schizophrenia and mental health.

⬇️ Subscribe to our channel for more valuable insights.

🔗Subscribe: https://www.youtube.com/@Schiz....ophreniaSupportNetwo

#Brexpiprazole #Rexulti #SchizophreniaTreatment #MentalHealth #Antipsychotics #MentalWellness #MedicationManagement #PatientSupport #QualityOfLife #SideEffects #SchizophreniaSupport #MentalHealthAwareness #PsychiatricMedication #MentalHealthEducation #LivingWithSchizophrenia

About Us: Welcome to the Schizophrenia Support Network, your resource for understanding schizophrenia and its impact on daily life. This channel focuses on key topics including schizophrenia symptoms, treatment options, living with schizophrenia, early signs of the condition, and how to manage it effectively. We aim to provide accurate information to help demystify schizophrenia and tackle common myths surrounding it, promoting a better understanding of schizophrenia and psychosis. The content provided is for general informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

Rexulti (Brexpiprazole) Withdrawal, Tapering, and Alternatives - Your Top Concerns Revealed Side Effects 3 Views • 5 months ago

Our treatment specialist and founder of ATMC, Lyle Murphy, answers your biggest concerns about the antipsychotic drug Rexulti (Brexpiprazole).

Q&A From you!

00:00 - Intro
00:22 - How are atypical antipsychotics like Rexulti different from other atypicals such as Seroquel and Zyprexa?
03:31 - What dopaminergic pathway is effected by Rexulti?
04:18 - Can you stop Rexulti cold turkey?
05:42 - How long does it take before you get addicted to Rexulti?
06:36 - The doctor prescribed me Sinequan 50mg, Rexulti 0.5 mg, and PMs-Duloxetine 60mg. Should I be concerned about raised sugar levels as I'm diabetic.
07:20 - How long does it take to withdraw off of Rexulti, 1 mg taken for two weeks?
09:55 - Is there a scenario for you to be prescribed rexulti and tentrellix together?
11:36 - Does stiff hand muscles caused by Rexulti fade with time as the body builds up tolerance against the medication?
12:45 - Why wasn't Rexulti approved for ADHD?
13:55 - How is Rexulti different from Abilify?
16:50 - Is it worth it to take try Rexulti if there was limited success with Abilify? It's supposed to be an improved version.
17:51 - How does a dopamine partial agonist like Rexulti interact with stimulants like Ritalin?
19:13 - Have you have seen good experiences taking Rexulti for depression? Is it safer than most?
20:48 - Can someone with trauma and psychosis still channel and be clairvoyant if they are taking Rexulti and Seroquel?
22:36 - How can the psychiatric drug Rexulti cost about 50% of the typical monthly income of a new employee in the US food industry, like the young woman shown in their commercial?
24:23 - ATMC

How Does Rexulti Work?
Rexulti works in the brain by balancing chemicals. More specifically, it is a serotonin-dopamine activity modulator (SDAM) that works with the dopamine and serotonin receptors inside the brain. Serotonin and dopamine are important neurotransmitters that nerve cells release and receptors in the brain pick up. Both serotonin and dopamine play a role in depression, but each works a little differently.

Dopamine Is a Motivator
Increasing dopamine may help with some depression symptoms, including low motivation, a loss of interest in things that used to be enjoyable, and thoughts of helplessness. This is because dopamine is the motivation and reward chemical. It’s why you get a rush when you complete a task. Dopamine helps people enjoy all kinds of activities. From food to sex, dopamine being released in the brain helps us enjoy those experiences. Unfortunately, it’s also what leads to addictions, including drugs, gambling, and shopping.

Dopamine Can Cause Problems for Users
Dopamine does not always get released at the same level. An activity that once brought a rush to a person may not be as exciting after a while. This means that a person may “use” more than they once did to get the same rush, whether it is a drug or another addiction. Dopamine dysfunction has been tied to bipolar disorder, major depressive disorder, attention deficit hyperactivity disorder (ADHD), and schizophrenia.

Rexulti Moderates Serotonin Activity Too

Serotonin can affect a person’s overall mood because serotonin helps a person process their emotions. Low serotonin levels were thought to be the cause of depression, but several decades of research have suggested that it is not quite that simple. The most effective non-holistic medicinal approach to depression is to increase serotonin levels in the brain by using selective serotonin reuptake inhibitors (SSRIs). Forty to 60 percent of people with moderate to severe depression who start SSRIs feel they are improving within six to eight weeks. That leaves a lot of patients not responding to the SSRIs. That’s why doctors may prescribe Rexulti (brexpiprazole) in addition to an SSRI for major depressive disorder.

Increased serotonin in the brain does not always equate to less depression. Instead, increased serotonin helps with positive emotional processing. Over time, that can result in an overall improvement in mood.

Serotonin has been linked to autism spectrum disorders, bipolar disorder, anxiety disorders, obsessive-compulsive disorder (OCD), and social anxiety disorder.

Not only do serotonin and dopamine affect a person’s mood, they can also affect a person’s sleep and digestion.

Read more at: https://www.alternativetomeds.....com/blog/brexpiprazo

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REPATHA: The STATIN Alternative Side Effects 4 Views • 5 months ago

Welcome back to Pharmacist Michael's Happy, Healthy, Living channel. In today's video, we're delving into the exciting world of Rapatha, a revolutionary medication that's reshaping cholesterol management.

Section 1: What's Rapatha All About?
Rapatha, also known as evolocumab, is causing a buzz in the healthcare scene. But what exactly is it? In simple terms, it's a medication engineered to lower LDL cholesterol, often referred to as the "bad" cholesterol. But here's the twist – it achieves this in a one-of-a-kind way. Let's dive right in!

Section 2: The Science Behind Rapatha
Imagine Rapatha as a secret agent working inside your body. Its mission? To target a protein named PCSK9, acting as a gatekeeper in your liver. This protein controls the number of "bad" cholesterol receptors your body has. When PCSK9 levels are elevated, your LDL cholesterol levels follow suit. Rapatha steps in, intercepting PCSK9, resulting in more receptors and less "bad" cholesterol circulating in your bloodstream.

Section 3: Who Stands to Gain from Rapatha?
So, who should be enthusiastic about Rapatha? It's a game-changer for individuals with exceptionally high cholesterol levels, especially those grappling with familial hypercholesterolemia, a genetic condition. If you're at significant risk of heart-related issues like heart attacks or strokes and other cholesterol medications aren't doing the trick, Rapatha might be your knight in shining armor. And for those who can't endure the side effects of statins, Rapatha could be a welcome alternative.

Section 4: How to Administer Rapatha
Taking Rapatha is a walk in the park. You administer it with a simple subcutaneous shot, right under your skin. No need for frequent doctor visits – you can do it in the comfort of your home. Your healthcare provider will guide you in determining the appropriate dosage and injection frequency based on your cholesterol levels.

Section 5: Possible Speed Bumps - Side Effects
Like most things in life, Rapatha can have its quirks, but they're typically minor. You might experience some localized redness, swelling, or discomfort at the injection site. Or you could feel like you have the flu temporarily, with symptoms like fever, chills, or muscle aches. The silver lining is that these side effects usually fade quickly. For most people, the benefits of lower cholesterol far outweigh these minor inconveniences.

Section 6: Wrapping it Up and Points to Consider
In a nutshell, Rapatha, or evolocumab, is a groundbreaking medication for managing cholesterol levels. Think of it as your cholesterol guardian angel, helping your body maintain cholesterol more effectively. And if you're interested in straightforward health content, consider becoming a part of our health community by subscribing. Thanks for tuning in, and we look forward to catching you in the next video. Stay healthy!

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This video cannot and does not contain medical/health advice. The medical/health information is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of medical health advice. THE USE OR RELIANCE OF ANY INFORMATION CONTAINED IN THIS VIDEO IS SOLELY AT YOUR OWN RISK.

LDL-Lowering PCSK9 Inhibitors: Why We Aren’t Using Them “All the Time Side Effects 1 Views • 5 months ago

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ABOUT THIS VIDEO: This topic was requested by a viewer, Joe Isaacs. He saw an article indicating that PCSK9 inhibitors decrease plaque deposition. So he's asking why I don't use them. I do, but so far only for Familial Hypercholesterolemia patients. This video tells why.

ABOUT DR. BREWER
Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Dr. Brewer provides services via telemedicine or in person if you're in the Lexington, KY area. We find a lot of undiagnosed Pre-Diabetes or Insulin Resistance. Treating unrecognized risk factors like Pre-Diabetes allows reduction of risk and prevention of disease.

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How-to Overview: Repatha® SureClick® Autoinjector Side Effects 2 Views • 5 months ago

Watch how to store, use, and discard the Repatha® SureClick® autoinjector (single-dose prefilled autoinjector). Read the full instructions before you inject! https://www.pi.amgen.com/unite....d_states/repatha/rep
Please keep reading for Approved Use and Important Safety Info.
Click “SHOW MORE" to jump to a section:
Start: (0:00)
Prepare: (0:40)
Inspect: (1:47)
Gather Materials: (2:16)
Select Site: (2:30)
Injection: (4:05)
Important Safety Information: (4:33)

Visit our Frequently Asked Questions page for more answers and check out our SureClick® Reference Guide.

Frequently Asked Questions: https://www.repatha.com/how-to....-start-repatha-injec
SureClick® Reference Guide: https://www.pi.amgen.com/-/med....ia/Project/Amgen/Rep

IMPORTANT SAFETY INFORMATION
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are
breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative
of latex) in the needle cover or are not made with natural rubber latex. The carton and “Instructions for Use” will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose
syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?
Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these
symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tonque, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or
bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

APPROVED USE
What is Repatha®?
Repatha® is an injectable prescription medicine used:
• To reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina)
requiring hospitalization, or certain types of heart surgery, in adults with cardiovascular disease.
• along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol
called heterozygous familial hypercholesterolemia [HeFH]) to reduce low density lipoprotein (LDL) or bad cholesterol

Please see full Prescribing Information at Repatha.com/PI and Patient Product Information at Repatha.com/PPI

How Repatha® Works Side Effects 6 Views • 5 months ago

Watch the Official How Repatha® Works video.

Please keep reading for Approved Uses and Important Safety Info.

IMPORTANT SAFETY INFORMATION
Do not use Repatha® if you are allergic to evolocumab or to any of the ingredients in Repatha®.

Before you start using Repatha®, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Repatha® is available as prefilled single-dose SureClick® autoinjectors and prefilled single-dose syringes that either contain dry natural rubber (a derivative of latex) in the needle cover or are not made with natural rubber latex. The carton and “Instructions for Use” will state if your prefilled single-dose SureClick® autoinjector or prefilled single-dose syringe contains dry natural rubber. The single-dose Pushtronex® system (on-body infusor with prefilled cartridge) is not made with natural rubber latex.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines, vitamins, or herbal supplements you take.

What are the possible side effects of Repatha®?
Repatha® can cause serious side effects including serious allergic reactions. Stop taking Repatha® and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

The most common side effects of Repatha® include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes) and redness, pain, or bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha®. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

APPROVED USE
What is Repatha®?
Repatha® is an injectable prescription medicine used:
· To reduce the risk of major adverse cardiovascular (CV) events, such as death from cardiovascular disease, heart attack, stroke, certain types of chest pain conditions (unstable angina) requiring hospitalization, or certain types of heart surgery, in adults with cardiovascular disease.
· along with diet alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low density lipoprotein (LDL) or bad cholesterol.

Please see full Prescribing Information at Repatha.com/PI and Patient Product Information at Repatha.com/PPI

Are PCSK9 Inhibitors for LDL Cholesterol Safe and Effective? Side Effects 4 Views • 5 months ago

Those with genetic mutations that leave them with an LDL cholesterol of 30 live exceptionally long lives. Can we duplicate that effect with drugs? And can LDL cholesterol levels get too low?

How can we decrease cholesterol with diet? See Trans Fat, Saturated Fat, and Cholesterol: Tolerable Upper Intake of Zero (https://nutritionfacts.org/vid....eo/trans-fat-saturat

For more on statin drugs, see:
• How Common Are Muscle Side Effects from Statins? (https://nutritionfacts.org/vid....eo/how-common-are-mu
• Who Should Take Statins? (https://nutritionfacts.org/vid....eo/who-should-take-s
• Are Doctors Misleading Patients About Statin Risks and Benefits? (https://nutritionfacts.org/vid....eo/are-doctors-misle
• The True Benefits vs. Side Effects of Statins (https://nutritionfacts.org/vid....eo/the-true-benefits
• How Much Longer Do You Live on Statins? (https://nutritionfacts.org/vid....eo/how-much-longer-d

If you missed the previous video, see Can Cholesterol Get Too Low? (https://nutritionfacts.org/vid....eo/can-cholesterol-g

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Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/vide....o/are-pcsk9-inhibito and someone on the NutritionFacts.org team will try to answer it.

Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/vid....eo/are-pcsk9-inhibit You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics.

Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM

Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/

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Key points about Repatha and Rapamycin Side Effects 3 Views • 5 months ago

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