Dosage and Administration

The dosage of Aceclofenac tablets may vary depending on the indication, severity of symptoms, and individual patient factors.

Generally, the recommended dose for adults is 100 mg twice daily. However, some patients may require higher doses, up to 200 mg twice daily, particularly in cases of severe pain and inflammation.

Aceclofenac tablets should be taken with food to reduce the risk of gastrointestinal side effects. They should be swallowed whole with a glass of water and should not be crushed or chewed.

The duration of treatment with Aceclofenac should be limited to the shortest possible time required to control symptoms, and the lowest effective dose should be used to minimize the risk of adverse effects.

Side Effects

Like other NSAIDs, Aceclofenac tablets may cause a range of side effects, which can vary in severity and frequency. Common side effects include:

1. Gastrointestinal disturbances: Such as dyspepsia, abdominal pain, nausea, and diarrhea.
2. Dizziness and headache.
3. Skin reactions: Including rash, itching, and photosensitivity.
4. Fluid retention and edema.
5. Elevated liver enzymes: Rare cases of hepatitis and liver damage have been reported with Aceclofenac use.
6. Renal impairment: NSAIDs can cause or worsen kidney dysfunction, particularly in patients with pre-existing renal disease.

Contraindications

Aceclofenac tablets are contraindicated in certain situations due to the potential for serious adverse effects. Contraindications include:

1. Hypersensitivity: Patients with a history of hypersensitivity reactions to Aceclofenac or other NSAIDs should avoid its use.
2. Severe heart failure: NSAIDs can exacerbate fluid retention and worsen heart failure symptoms.
3. Peptic ulcer disease: Due to the risk of gastrointestinal bleeding and perforation.
4. Severe renal impairment: Aceclofenac should be used with caution or avoided in patients with severe renal dysfunction.

Clinical Efficacy

Clinical studies have demonstrated the efficacy of Aceclofenac tablets in the management of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute musculoskeletal disorders.

Aceclofenac has been shown to provide rapid and sustained relief of symptoms, including pain intensity, joint swelling, and functional impairment. It is generally well tolerated, with a favorable gastrointestinal safety profile compared to some other NSAIDs.

Safety Profile

Overall, Aceclofenac has a favorable safety profile when used at recommended doses and durations. However, like all NSAIDs, it is associated with the risk of gastrointestinal, cardiovascular, renal, and hepatic adverse effects. Healthcare providers should carefully assess the risks and benefits
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