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Amitriptyline (Elavil)
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• 08/17/25
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Outline Generic Name
Amitriptyline
Trade Name
Elavil
Indication
Depression, anxiety, insomnia, parkinson’s
Action
Increases effect of serotonin and norepinephrine in the CNS, exhibits anticholinergic effects
Therapeutic Class
Antidepressant
Pharmacologic Class
Tricyclic antidepressant
Nursing Considerations
• Contraindicated in MI, heart failure, QT prolongation, glaucoma • May increase risk for suicidal ideation • May cause arrhythmias, hypotension, EKG changes • May cause alterations in blood glucose levels • May lead to general sedation and lethargy • Do not use within 2 weeks of MAOIs • Instruct pt to take medication exactly as instructed • Monitor for orthostatic hypotension • May lead to photosensitivity, instruct patient to use sunscreen • May turn urine blue/green color.
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