Antacids, H2 blockers, PPIs, and sucralfate—what do they all have in common? They prevent and treat GI ulcers! But they all work differently, so here’s a quick breakdown:

Antacids
* Neutralize stomach acid (e.g., sodium bicarb, calcium carbonate)
* Work quickly but not long-lasting

H2 Blockers (-tidine)
* Block H2 receptors to reduce acid production
* Onset 30-60 mins, longer duration than antacids
* Risk of B12 deficiency with long-term use

Proton Pump Inhibitors (PPIs) (-prazole)
* Inhibit proton pump in parietal cells, decreasing acid production
* Take longer to go into full effect but typically longer lasting effects
* Risk of osteoporosis with long-term use

Sucralfate
* Mucosal protectant that forms a thick paste to coat ulcers
* Commonly used for duodenal ulcers
* Take 1 hour before meals → Think suCralfate Coats the stomach

💬 Comment below with other meds you’d like to see covered!

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