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Auvelity Dextromethorphan/ Buproprion for Depression treatment MDD in Philadelphia
Auvelity (dextromethorphan/ buproprion) is an NMDA Antagonist and a newer type of medication used in the treatment of Depression (Major Depressive Disorder) at our Philadelphia office. This medication's primary effective agent is dextromethorphan (which is commonly used in cough medications / antitussives). The buproprion (also known as Wellbutrin) in this combination pill works to decrease the effectiveness of a liver enzyme that breaks down dextromethorphan (CYP2D6) thereby increasing the dextromethorphan blood concentration and allowing it to have a longer duration of action, than when it's used for colds (dextromethorphan breaks down relatively quickly). Wellbutrin is an antidepressant, but trials indicate that the dextromethorphan is the medication in this pill, the predominantly is resulting in improved mood. Dextromethorphan works as an N-Methyl-D-Aspartate (NMDA) antagonist increasing Glutamate levels (again, this is a relatively novel pathway to treat depression). If an individual has failed several anti-depressants, utilizing a different method of treatment (or pathway for treatment) may be a good option. Side effects can include dizziness, nausea and headache (among others). Severe side effects can include elevated blood pressure, severe rash or others. However, most tolerate it well, with per manufacturer, less than a 15% discontinuation rate, due to side effects.
Please talk to your provider about all risks and benefits of this medication before starting, stopping or changing doses. This information is meant to educate providers and give patients more information to discuss with them about their options.
Dr. Pagnani is the Medical Director of Rittenhouse Psychiatric Associates in Philadelphia, PA and surrounding areas. Their practice has 25 Academically oriented provides and is now scheduling in-office and telemedicine visits.
For additional informative mental health videos:
youtube.com/@rittenhousepsych
www.RittenhousePA.com
www.ChrisPagnaniMD.com
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