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Bismuth subsalicylate (Pepto-Bismol) pharmacology, GI drugs pharmacology, pharmacology made easy

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pharmacology, bismuth subsalicylate, pepto-bismol, bismuth subsalicylate pharmacology, pharmacology lectures for pharmacy students, clinical pharmacology lectures,

๐Ÿ’Š Bismuth subsalicylate acts as an antimicrobial, anti-inflammatory, and antisecretory agent. It binds enterotoxins and inhibits their action, reducing intestinal secretions and inflammation.
๐Ÿ’Š Bismuth subsalicylate (e.g., Pepto-Bismol) is primarily used for acute diarrhea, including travelerโ€™s diarrhea, and as part of H. pylori eradication regimens.
๐Ÿ’Š Bismuth can react with sulfur in saliva and GI tract, producing black-colored tongue and stools โ€” a harmless and reversible effect.
๐Ÿ’Š Chronic use or overdose can lead to salicylate toxicity, with symptoms like tinnitus, confusion, and metabolic acidosis.
๐Ÿ’Š Like other salicylates, bismuth subsalicylate is contraindicated during pregnancy (especially third trimester) and in children due to Reyeโ€™s syndrome risk.
๐Ÿ’Š Bismuth subsalicylate contains salicylate, which can increase bleeding risk when combined with anticoagulants like warfarin.
#salicylates #peptobismol #pharmacologylectures #clinicalpharmacology #pepticulcer

Chapters:
0:00 - bismuth subsalicylate pharmacology
0:27 - bismuth subsalicylate mechanism of action
1:32 - bismuth subsalicylate pharmacokinetics
2:05 - bismuth subsalicylate side effects
2:37 - bismuth subsalicylate contraindications
3:03 - bismuth subsalicylate drug interactions

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