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![ANTIBIOTICS [COMMON SIDE EFFECTS] GPHC EXAM](https://i.ytimg.com/vi/P-sOwqPdAyo/maxresdefault.jpg)
Ceftriaxone Antibiotics
Ceftriaxone Antibiotics
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#howtouseceftriaxone
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CEFTRIAXONE
Class: Third-generation cephalosporin antibiotic
Spectrum: Broad-spectrum; effective against Gram-positive and Gram-negative bacteria
Indications:
- Severe infections (sepsis, meningitis)
- Community-acquired pneumonia
- Gonorrhea (including penicillin-resistant strains)
- Lyme disease (alternative)
- Intra-abdominal infections (with metronidazole)
- Surgical prophylaxis (selected cases)
Dosing:
- Adults: 1–2 g IV/IM once daily (up to 4 g/day in severe infections)
- Pediatrics: 50–100 mg/kg/day (max 4 g/day)
- Meningitis: 100 mg/kg/day (max 4 g/day)
Administration:
- IV (over 30 mins) or IM (with lidocaine for pain)
- NOT for intraventricular or intrathecal use
Side Effects:
- Diarrhea, nausea, rash
- Transient LFT abnormalities
- Biliary sludge/"pseudolithiasis" (with prolonged use)
- Hematologic (eosinophilia, thrombocytosis, rarely neutropenia)
Contraindications:
- Hypersensitivity to cephalosporins
- Severe penicillin allergy (cross-reactivity risk)
- Neonates (if calcium-containing solutions due to precipitation risk)
Drug Interactions:
- Calcium-containing solutions: Risk of precipitation (avoid concurrent IV use in neonates)
- Warfarin: Increased INR (monitor coagulation)
- Probenecid: Delays renal excretion
- Pregnancy/Lactation: Category B; excreted in breast milk (use with caution)
Disclaimer:
Video is for educational purpose only Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research Fair use is a use permitted by copyright statute that might otherwise be infringing Non-profit, educational or personal use tips the balance in favor of fair use Some photos in the video are downloaded from Google Image. The picture used in this video is protected by the Fair Use Law, section 107 used for commentaries, criticisms, news reports or Education for transformative use.
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