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Major depressive disorder
Vasomotor symptoms associated with menopause
Desvenlafaxine
Khedezla - Pristiq
Brand Names: Canada
AG-Desvenlafaxine; APO-Desvenlafaxine; APO-Desvenlafaxine ER; JAMP-Desvenlafaxine; Pristiq; PRO-Desvenlafaxine; TEVA-Desvenlafaxine
Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor
US Boxed Warning
Suicidal thoughts and behavior:
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behaviors with antidepressant use in adults older than 24 years; there was a reduction in risk with antidepressant use in adults 65 years and older. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. Desvenlafaxine is not approved for use in pediatric patients.

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