In this video, we review the popular antidepressant, mirtazapine. Mirtazapine is indicated for depression but may also be used in PTSD, OCD and insomnia. Mirtazapine has a unique mechanism of action that gives it an interesting side effect profile - drowsiness and weight gain are common while sexual dysfunction and nausea are rare. A large network meta analysis found that mirtazapine stacks up favourably compared to other antidepressants in terms of efficacy and acceptability. In my opinion, Mirtazapine is best suited for those with depression and insomnia who do not mind gaining a bit of weight.

References:
Product monograph: https://www.merck.ca/static/pd....f/REMERON_RD-PM_E.pd
Mechanism of action: https://www.ncbi.nlm.nih.gov/books/NBK519059/
Network meta analysis: https://www.thelancet.com/jour....nals/lancet/article/

Hope this video is helpful!

All the best,

Isaac

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