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Flagyl
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• 08/19/25
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Side Effects
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Flagyl or Metronidazole became available in 1963 to treat the common sexually transmitted infection from the parasite Trichomonas vaginalis referred to as “trich.” Several decades later Flagyl was approved for treatment of bacterial vaginosis.
Along the way Flagyl was found to be active active against a wide array of infections caused by anaerobic bacteria which grow without utilizing oxygen. This increasingly important group includes Bacteroides and Clostridium. These agents cause peritonitis resulting from diverticulitis and appendicitis as well as heart valve infections, brain abscesses and lung infections. Amoebic dysentery also responds to Flagyl.
Adverse reactions to Flagyl include a sharp metallic taste in the mouth, nausea, headache, overgrowth of yeast in the mouth or vagina and dizziness. Alcohol combined with Flagyl precipitates a horrible effect; similar problems occur with the drug Antabuse.
Flagyl is a possible carcinogen according the WHO and U.S. National Toxicology Program. Recent investigations in mice demonstrate Flagyl may be useful in treating endometriosis. Whether this will transition to humans remains to be evaluated.
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