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Griseofulvin As an Antifungal Drug ; Mechanism of action, Pharmacokinetics, Uses, Effects
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• 08/19/25
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Griseofulvin is an antifungal medication primarily used to treat dermatophyte infections, which affect the skin, hair, and nails. Here's an overview of its key aspects:
Mechanism of Action
Griseofulvin works by binding to keratin in the skin, hair, and nails, making these tissues resistant to fungal invasion. It also disrupts fungal cell division by interfering with microtubule function, which inhibits fungal growth.
Indications
Griseofulvin is effective against:
Tinea infections: Such as ringworm, athlete's foot (tinea pedis), and jock itch (tinea cruris).
Onychomycosis: Fungal infections of the nails.
Scalp infections: Caused by dermatophytes.
Dosage Forms
It is available in oral formulations, including:
Tablets.
Capsules.
Oral suspensions.
Side Effects
Common side effects include:
Nausea, vomiting, and diarrhea.
Headache and dizziness.
Skin rashes or photosensitivity. Rare but serious effects may include liver toxicity and allergic reactions.
Clinical Considerations
Griseofulvin is typically taken with fatty meals to enhance absorption.
It is contraindicated in patients with liver disease or porphyria.
Women should avoid pregnancy during treatment due to potential teratogenic effects.
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