Griseofulvin - Mechanism of action, Side effects, and Indications

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Side Effects

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Griseofulvin is an antifungal medication that is primarily used to treat fungal infections of the skin, hair, and nails. It belongs to a class of drugs known as antifungals, and it is particularly effective against dermatophyte fungi, which are responsible for many common fungal infections of the skin and nails.

Here are some key points about Griseofulvin:

1. Mechanism of Action: Griseofulvin works by inhibiting the growth of fungi. It does this by disrupting the formation of the fungal cell wall, which is essential for the fungus's survival and replication. This mechanism of action makes it effective against a wide range of dermatophyte fungi.

2. Indications: Griseofulvin is typically prescribed to treat fungal infections such as ringworm (tinea corporis), athlete's foot (tinea pedis), jock itch (tinea cruris), and fungal infections of the nails (onychomycosis). It is also occasionally used for more severe fungal infections when other antifungal medications are ineffective.

3. Administration: Griseofulvin is usually available in the form of oral tablets or capsules. It is taken by mouth, typically with a fatty meal, as this enhances its absorption. The treatment duration can vary depending on the severity and location of the fungal infection but is often several weeks.

4. Side Effects: Common side effects of Griseofulvin may include gastrointestinal upset, such as nausea, vomiting, and diarrhea. It can also cause headaches, dizziness, and skin rashes. More serious side effects are rare but can include liver problems, blood disorders, and allergic reactions.

5. Precautions: Griseofulvin may interact with other medications, so it's important to inform your healthcare provider about any other drugs you are taking. It is typically not recommended for use during pregnancy or breastfeeding. Additionally, it can make some people more sensitive to sunlight, so sun protection is advised during treatment.

6. Effectiveness: Griseofulvin is generally effective for treating fungal infections caused by dermatophytes. However, it may not be the first choice for all infections, especially if newer antifungal medications with fewer side effects and shorter treatment durations are available.

7. Monitoring: While taking Griseofulvin, your healthcare provider may monitor your liver function with blood tests, as this medication can rarely cause liver problems.

It's important to note that Griseofulvin is a prescription medication, and its use should be supervised by a healthcare professional. If you suspect you have a fungal infection or have been prescribed Griseofulvin, it's essential to follow your doctor's instructions carefully and complete the full course of treatment to ensure the infection is effectively eradicated.

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