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How Long Does Diphenhydramine Stay in Your System?
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• 08/18/25
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Diphenhydramine (Benadryl) is an antihistamine that’s often found in over-the-counter (OTC) allergy relief medications.
You can purchase OTC drugs at grocery stores, drug stores, and pharmacies without a prescription.
Although diphenhydramine is commonly used in OTC medications, it can also produce a high and even cause dependence.
The half-life of diphenhydramine determines how long its side effects last and how long it stays in a person’s body.
Additionally, factors like weight, age, and the dosage taken can also influence the results of a drug test.
So, how long does diphenhydramine stay in your system?
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