How long does it take for Excedrin Migraine to work Key PointsExcedrin Migraine can work as quickly as minutes to relieve your migraine painIn clinical studies patients with moderate to severe migraines experienced pain relief with one dose and it lasted up to hoursExcedrin Migraine is taken as soon as your migraine headache begins It is not used to prevent migraine headachesWhats in Excedrin HeadacheEach caplet or geltab of Excedrin Migraine contains milligrams mg of caffeine mg of acetaminophen and mg of aspirin Caffeine increases the effects of pain medicines like aspirin and acetaminophen and can make these medicines more effectiveThe regular dosage for adults is caplets or geltabs with a full glass of waterDo not take more than two caplets or geltabs in any hour period unless directed by your doctorIf symptoms worsen or persist contact your doctorIf you are under years of age ask a doctor before useThe recommended dose of Excedrin Migraine contains roughly as much caffeine as a cup of coffee Limit caffeinecontaining medications foods or beverages while using Excedrin Migraine Excessive caffeine can cause nervousness irritability sleeplessness and rapid heart beatIf you have migraine headaches that are not responding to any overthecounter OTC medicines contact your doctor for further evaluation There are many prescription treatments available for migraine that may be helpful for youOverthecounter generic and storebrands of Excedrin Migraine are available in the USRelated Review of Migraine TreatmentHow long does Excedrin Migraine lastIn three placebocontrolled studies an acetaminophen aspirin and caffeine combination equivalent to Excedrin Migraine was shown to last up to hours when taken to relieve migraine headache painSignificant pain relief rated as mild or none began in minutes in the group receiving the acetaminophen aspirin and caffeine combination compared to placebo in a pooled analysis of all three studiesTwo hours after taking the dose the pain intensity was reduced to mild or none in of patients in the drugtreated group compared to of patients in the placebo groupAt six hours after taking the dose of those taking the active drug and of placebotreated patients rated pain as mild or none Also at six hours after the dose of drugtreated patients and of placebotreated patients reported being painfreeAt all time points results were found to be statistically significant when compared to placeboOther migraine headache symptoms such as nausea sensitivity to light and sound and inability to carry out usual daily activities functional disability were also significantly improved to hours after treatment with the acetaminophen aspirin and caffeine combination when compared with a placeboRead More Side effects and warnings for Excedrin MigraineThis is not all the information you need to know about Excedrin Migraine for safe and effective use and does not take the place of talking to your doctor about your treatment Review the full Excedrin Migraine information here and discuss this information and any questions you have with your doctor or other health care providerRelated questions Can you take Excedrin Migraine while pregnant How much caffeine is in Excedrin Migraine Staying Safe while taking Acetaminophen

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