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Lamotrigine side effects | Lamotrigine ER tablet side effect | Side effect of lamotrigine tablet

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This video explains the side effects of lamotrigine tablets. @ProfessorTushar

Some more information on lamotrigine tablets (for educational purposes only; not for a substitute for professional medical advice).

Sinusistis attribution:
BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. / CC BY (https://creativecommons.org/licenses/by/3.0)
https://upload.wikimedia.org/w....ikipedia/commons/f/f

Mechanism of Action of lamotrigine:
The precise mechanism(s) by which lamotrigine exerts its anticonvulsant action are unknown. In
animal models designed to detect anticonvulsant activity, lamotrigine was effective in preventing
seizure spread in the maximum electroshock (MES) and pentylenetetrazol (scMet) tests, and
prevented seizures in the visually and electrically evoked after-discharge (EEAD) tests for
antiepileptic activity. Lamotrigine also displayed inhibitory properties in the kindling model in
rats both during kindling development and in the fully kindled state. The relevance of these
models to human epilepsy, however, is not known.
One proposed mechanism of action of lamotrigine, the relevance of which remains to be
established in humans, involves an effect on sodium channels. In vitro pharmacological studies
suggest that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal
membranes and consequently modulating presynaptic transmitter release of excitatory amino
acids (e.g., glutamate and asp)

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