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Novel agent combinations for CLL: ibrutinib, venetoclax, obinutuzumab and zanubrutinib
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• 08/29/25
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There are a growing number of investigations of novel combination therapies for chronic lymphocytic leukemia (CLL). These are discussed in this interview with Peter Hillmen, MBChB, PhD, FRCP, FRCPath, from Leeds Teaching Hospital NHS Trust, Leeds, UK, which took place at the American Society of Oncology (ASCO) 2018 Annual Meeting, held in Chicago, IL. Prof. Hillmen provides an insight into the novel agents currently in trials, as well as the pros and cons of ibrutinib, and how it stacks up against a next-generation BTK inhibitor combination that is more specific, tolerable and has shown fewer side effects for CLL patients.
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