Olanzapine vs Risperidone for Bipolar and Schizophrenia

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In today's video, we are comparing 2 older second-generation antipsychotics, olanzapine, and risperidone. Time stamps of each topic covered are listed below:

Intro 00:00
How do olanzapine and risperidone work? 00:23
What are olanzapine and risperidone used for? 03:27
Side effects of olanzapine and risperidone 04:53
Considerations of taking olanzapine and risperidone 07:36
- Black box warning 07:50
- Monitor Labs 08:25
- Neuroleptic Malignant Syndrome 10:31
- Extra Pyramidal Symptoms 11:03
- Orthostatic Hypotension 12:39
- Seizures 13:20
Final thoughts 14:02

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📚 Useful Resources:
Deprescribing Guide: : https://amzn.to/4dZEUMk
Drug Interaction Checker-https://www.drugs.com/drug_interactions.html
Brain Food Report- https://www.levelheadedmind.com/brainfoodreport
Neurotransmitter Questionnaire- https://www.levelheadedmind.co....m/neurotransmitter-a

🎥 This video was edited by:
Rahul Kanchi https://www.linkedin.com/in/rahulkanchi24/

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References:
Alsherbiny MA, Li CG. Medicinal Cannabis-Potential Drug Interactions. Medicines (Basel). 2018 Dec 23;6(1):3. doi: 10.3390/medicines6010003. PMID: 30583596; PMCID: PMC6473892.

He, S., Yu, W. J., Wang, X., Zhang, L., Zhao, N., Li, G., Shen, Y. F., & Li, H. (2020). Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids. General psychiatry, 33(4), e100206. https://doi.org/10.1136/gpsych-2020-100206

Olanzapine FDA Label (2009). Retrieved from https://www.accessdata.fda.gov..../drugsatfda_docs/lab

Risperdal FDA Label (2009). Retrieved from https://www.accessdata.fda.gov..../drugsatfda_docs/lab

Shoja Shafti, S., & Gilanipoor, M. (2014). A Comparative Study between Olanzapine and Risperidone in the Management of Schizophrenia. Schizophrenia research and treatment, 2014, 307202. https://doi.org/10.1155/2014/307202

Stahl, S. M., Grady, M. M., & Muntner, N. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.

Stahl, S. (2017). Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 6th Ed. Cambridge University Press.

Uptodate (2022). Olanzapine: Drug Information. Retrieved from https://www-uptodate-com.libproxy.eku.edu/contents/olanzapine-drug-information?source=auto_suggest&selectedTitle=1~3---1~3---Olanzapine&search=olanzapine#F203123

UptoDate (2022). Risperidone: Drug information. Retrieved from https://www-uptodate-com.libproxy.eku.edu/contents/risperidone-drug-information?source=auto_suggest&selectedTitle=1~1---1~4---Risperdal&search=risperdal#F218620

Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

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