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Pharmacology of Lebrikizumab (Ebglyss); Mechanism of action, Uses, Effects, Pharmacokinetics
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• 08/29/25
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Lebrikizumab (Ebglyss) is a monoclonal antibody that targets interleukin-13 (IL-13), a cytokine involved in atopic dermatitis (eczema). It is used for moderate-to-severe atopic dermatitis in patients who require systemic therapy2.
Pharmacology
Mechanism of Action:
Lebrikizumab binds to IL-13, preventing its interaction with IL-13 receptors.
This reduces inflammation and improves skin barrier function.
Absorption: Administered subcutaneously, with peak levels reached in 6 days.
Metabolism: Cleared via proteolytic degradation.
Elimination: Slow clearance, with a half-life of ~23 days.
Clinical Uses
Atopic Dermatitis: Approved for moderate-to-severe cases.
Investigated for other inflammatory conditions.
Adverse Effects
Conjunctivitis & keratitis (eye inflammation).
Injection site reactions (pain, redness, swelling).
Herpes zoster infections (reported in clinical trials).
Avoid live vaccines during treatment
#Lebrikizumab
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