Unisom vs Benadryl Review: Differences & Similarities (What's Better?)

1 Views • 08/18/25

Side Effects

Subscribers

Unisom SleepTabs: https://amzn.to/2TigyGc
Benadryl UltraTabs: https://amzn.to/2IpEl13

Read our full comparison of the two including side effects, pros, cons, FAQ, etc here:
https://sleepinglucid.com/unis....om-vs-benadryl-diffe

FDA considers Unisom’s active ingredient doxylamine succinate to be safe for pregnant women. It's even sometimes recommended to women experiencing morning sickness symptoms.

Doxylamine succinate is a first-generation antihistamine. That's why it has a central effect on our bodies. This is also the reason why it is used as a sedative agent in Unisom.

Benadryl also has a first-generation antihistamine for its active ingredient diphenhydramine. This drug is mostly used to treat allergies but since it has a strong sedative action, people use it to help with insomnia too. Its relaxing effect is useful in preventing and treating motion sickness.

Effectivity and dosage: adults and teens above 12 years can take one Unisom SleepTabs 30 minutes before their bedtime. However, many users recommend that you start with a smaller dosage and slowly increase it until you find the dosage that fits you.

Also, remember that it's only meant for occasional sleeplessness. You shouldn’t take it for more than 14 days. Otherwise, your body will get accustomed to getting help in falling asleep, making it harder for you to sleep. The effects of doxylamine can last up to 10 or 12 hours. Make sure to only take it when you have ample time to sleep.

Related:
Melatonin vs Diphenhydramine: https://sleepinglucid.com/mela....tonin-vs-diphenhydra
ZzzQuil vs Benadryl: https://sleepinglucid.com/zzzq....uil-vs-benadryl-same
ZzzQuil vs NyQuil: https://sleepinglucid.com/zzzq....uil-vs-nyquil-differ

You can take up to 50 mg of diphenhydramine to help you to fall sleep. That means you can only take 2 Benadryl UltraTabs max. Only adults and children older than 12 should take Benadryl as a sleep aid. You can expect Benadryl to start to kick in about half an hour after taking it. After that, you’ll be able to feel its effects for 4-6 hours. Just like Unisom, only take Benadryl as a sleep medication occasionally.

Take note of the following precautions when taking Unisom:
Though doxylamine is regarded as safe for pregnant women, the drug can pass through breast milk. It's not recommended that lactating mothers take this sleep aid.
Kids under 12 should not take Unisom.
It's non-habit forming but can cause dependence if taken for a long time

If you’re planning to take Benadryl, here are some things that you need to keep in mind:
Never do anything that requires concentration after taking Benadryl. This includes driving and operating machinery.
Do not take tranquilizers or consume alcohol if you’ve taken this sleep aid.
If you have a history of conditions such as glaucoma, heart disease, diabetes, and asthma, check with your doctor first before taking Benadryl. The same goes if you’re currently taking medication or supplements.

In Conclusion, Unisom and Benadryl are both fast-acting, affordable and very effective sleep aids that can be bought without a prescription.

Their key difference lies in their half-life which is longer for Unisom and that Benadryl is also an allergy medicine.

So, if you’re not sick and just want to get some rest, I suggest trying out the Unisom first.

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