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What is ONDANSETRON (Zofran)? What is Ondansetron used for? Uses and Side Effects!
What is ONDANSETRON (Zofran)? What is Ondansetron used for? Uses and Side Effects!
Ondansetron, also known as Zofran®, is a medication primarily used to prevent and treat nausea and vomiting resulting from chemotherapy, radiation therapy, or surgery. It comes in several oral forms:
Tablets of 4 mg and 8 mg
A clear liquid solution
A white, round, disintegrating tablet known as ondansetron ODT, in 4 mg and 8 mg doses, which dissolves on the tongue
Additionally, ondansetron can be administered as a clear liquid via intravenous (IV) infusion.
Potential Side Effects of Ondansetron
Common side effects include:
Headaches
Abdominal pain
Diarrhea or constipation
Fatigue
Blurred vision
Skin rashes
Dizziness
Temporary liver function changes
These are not all the possible side effects, and any side effects should be reported to a healthcare provider.
Specific Instructions for Ondansetron Use
If ondansetron causes headaches, acetaminophen (Tylenol®) may be recommended for relief.
For the orally disintegrating tablet (ODT), do not push the tablet through the foil. Instead, peel the foil with dry hands and gently remove the tablet, placing it on your tongue to dissolve quickly. No liquid is needed for this form.
Ondansetron can control nausea and vomiting for up to 8 hours. If you experience nausea or vomiting between doses (known as “breakthrough” symptoms), inform your healthcare provider for potential additional medication.
Store ondansetron tablets and liquid at room temperature in a dry area.
Laboratory Testing and Ondansetron
The body's enzyme, cytochrome P450 2D6 (CYP2D6), is capable of metabolizing various medicines, including ondansetron. Genetic testing can reveal if your CYP2D6 metabolizes medicines at an abnormal rate. If your body processes medicines faster than usual, you might be advised against using ondansetron, as it may not be effective. Consult your healthcare provider for more information on CYP2D6 and its impact on ondansetron.
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