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What is Tacrolimus? What is Tacrolimus used for?

Tacrolimus, known commercially as Prograf®, is a medication that suppresses the immune system. Its primary use is to reduce the body’s natural immune response, helping prevent or manage graft-versus-host disease (GVHD) in patients who have undergone bone marrow transplantation.

Tacrolimus is available in capsule forms of 0.5 mg, 1 mg, and 5 mg, as well as an orally-administered suspension (liquid) prepared by pharmacies. It can also be administered as a clear liquid through intravenous infusion (IV).

Potential Side Effects of Tacrolimus

Initial Side Effects:

Nausea and vomiting
Later Side Effects (occurring usually after one day of treatment):
Reduced kidney function
Diminished liver function
High blood pressure
Headaches
Increased infection risk
Abdominal pain
Insomnia
Tremors
Visual disturbances
Seizures
Low blood magnesium
Elevated blood potassium
High blood sugar levels
These are some common side effects, but others may also occur.

Specific Usage Instructions for Tacrolimus

Tacrolimus should be taken either one hour before or two hours after meals on an empty stomach. If stomach issues arise, it can be taken with food.
Consistency is key. Take it at the same time each day, maintaining a consistent relationship with meal times to ensure stable tacrolimus levels in the body.

Capsules must be swallowed whole without crushing, cutting, or chewing.
Store capsules at room temperature and shake the oral liquid well before each use. Dispose of any remaining liquid after the expiration date.
Keep out of reach of children and pets.
If a dose is missed and there's more than 4 hours until the next dose, take it immediately. If the next dose is due within 4 hours, skip the missed dose and continue as scheduled. Never double dose unless directed.
Mix liquid tacrolimus with orange or apple juice (avoid grapefruit juice) for improved taste, and consume immediately.
Re-administer the dose if vomiting occurs within 20 minutes of taking it.
Drink plenty of fluids to reduce kidney damage risk.
Avoid antacids like Tums® or Mylanta® within 2 hours of taking tacrolimus.
Regular blood tests will monitor potassium, magnesium, kidney, and liver function.
Ensure a consistent supply of the medication, contacting the pharmacy for refills when necessary.
Tacrolimus increases sun sensitivity; wear protective clothing and sunscreen, and avoid direct sun exposure and tanning bulbs.
Some medications can affect tacrolimus levels or side effects. Always inform healthcare providers about all medications being taken.
When receiving tacrolimus via IV, it will be administered over 24 hours in a hospital setting with monitoring by medical staff.
Blood levels of tacrolimus will be regularly checked. Do not take the medication on the day of a blood test until after the sample is collected. Inform your doctor or pharmacist if tacrolimus has been taken before the test.

00:00 Tacrolimus Introduction
00:22 Side Effects
01:10 Usage Instructions
02:07 Important Precautions
03:26 Blood Level Tests

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What is TACROLIMUS? What is TACROLIMUS used for? Uses, Side Effects and dose (PROGRAF)

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