What to avoid when taking Chlorthalidone? #chlorthalidone #hypertension #heartfailure

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Warnings
You should not use chlorthalidone if you are unable to urinate, or if you are allergic to sulfa drugs.
Before taking this medicine
You should not use chlorthalidone if you are allergic to it, or if:
• you are unable to urinate; or
• you are allergic to sulfa drugs.
Tell your doctor if you have ever had:
• kidney disease;
• heart failure;
• gout;
• high cholesterol or triglycerides;
• diabetes; or
• if you are on a low-salt diet.
Tell your doctor if you are pregnant or plan to become pregnant.
Taking chlorthalidone during pregnancy may cause side effects in the newborn baby, such as jaundice (yellowing of the skin or eyes), bruising or bleeding, low blood sugar, or an electrolyte imbalance.
Do not start or stop taking chlorthalidone during pregnancy without your doctor's advice.
Although chlorthalidone may cause side effects in a newborn, having high blood pressure during pregnancy can cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.
You should not breastfeed while using chlorthalidone.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking chlorthalidone. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated.
Chlorthalidone can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorthalidone.
Major Drug Interactions of Chlorthalidone
Allopurinol
Using allopurinol together with chlorthalidone can increase your risk of serious skin reactions.
Call your doctor immediately if you experience symptoms such as a rash, itching, fever, or chills.
If your doctor does prescribe these medications together, you may need a dose adjustment and closer monitoring to safely use both medications.
Amiodarone
Talk to your doctor before using amiodarone together with chlorthalidone. Combining these medications can increase the risk of an irregular heart rhythm that may be serious.
If your doctor prescribes these medications together, you may need regular monitoring of your electrolyte (magnesium, potassium) levels as well as other tests to safely use both medications.
You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with amiodarone.
In addition, you should let your doctor know if you experience signs of electrolyte disturbance such as weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting.
Cisapride
Using cisapride together with chlorthalidone is not recommended. Combining these medications can increase the risk of an irregular heart rhythm that may be serious.
You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with cisapride.
Lithium
Ask your doctor before using chlorthalidone and lithium. Using chlorthalidone together with lithium can increase the effects of lithium. This may cause diarrhea, vomiting, drowsiness, tremor, thirst, increased urination, lack of coordination, or muscle weakness.
You may need a dose adjustment or special test to safely use both medications.
Sodium Nitrite
When use of sodium nitrite is required, the doctor should be told if you have been receiving treatment with chlorthalidone. Sodium nitrite can cause hypotension (low blood pressure), and the risk may be greater when combined with other medications that decrease blood pressure such as chlorthalidone.
Excessively low blood pressure can lead to shock, collapse, coma, or even death. Your doctor will need to monitor you closely and possibly take extra precautions for you to safely use these medications together.
Tizanidine
TiZANidine and chlorthalidone may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption.
Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome.

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